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    Kmt2b lysine (K)-specific methyltransferase 2B [ Mus musculus (house mouse) ]

    Gene ID: 75410, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kmt2bprovided by MGI
    Official Full Name
    lysine (K)-specific methyltransferase 2Bprovided by MGI
    Primary source
    MGI:MGI:109565
    See related
    Ensembl:ENSMUSG00000006307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ml; Wbp; Mll2; Wbp7; mKIAA0304; 2610014H22Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 33.1), spleen adult (RPKM 20.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kmt2b in Genome Data Viewer
    Location:
    7; 7 B1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30268280..30288371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30568855..30589056, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31353874..31373745, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene presenilin enhancer gamma secretase subunit Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1 Neighboring gene microRNA 3569 Neighboring gene zinc finger and BTB domain containing 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone methyltransferase activity (H3-K4 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone methyltransferase activity (H3-K4 specific) ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables histone-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K4 dimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-K4 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H3-K4 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-K4 monomethylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histone H3-K4 trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within histone lysine methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within oocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ovulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of histone H3-K4 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase 2B
    Names
    WBP-7
    WW domain binding protein 7
    histone-lysine N-methyltransferase MLL4
    lysine N-methyltransferase 2B
    mixed lineage leukemia 2
    myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog
    trithorax homolog 2
    NP_001277502.1
    NP_083550.2
    XP_006540471.1
    XP_011249035.1
    XP_036009396.1
    XP_036009397.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290573.1NP_001277502.1  histone-lysine N-methyltransferase 2B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC167970, BC056344
      UniProtKB/TrEMBL
      Q6PHU4
      Conserved Domains (10) summary
      cd05493
      Location:13801522
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:24202504
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:25842704
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:25662722
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:9631010
      zf-CXXC; CXXC zinc finger domain
      cd15589
      Location:12091255
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:12571306
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:13431399
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:15871691
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      pfam05964
      Location:17401786
      FYRN; F/Y-rich N-terminus
    2. NM_029274.2NP_083550.2  histone-lysine N-methyltransferase 2B isoform 2

      See identical proteins and their annotated locations for NP_083550.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB182318, CJ121348, CJ240818, U92455
      Consensus CDS
      CCDS21101.1
      UniProtKB/Swiss-Prot
      O08550
      Related
      ENSMUSP00000103789.3, ENSMUST00000108154.9
      Conserved Domains (10) summary
      cd05493
      Location:13801522
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:24112495
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:25752695
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:25572713
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:9631010
      zf-CXXC; CXXC zinc finger domain
      cd15589
      Location:12091255
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:12571306
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:13431399
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:15871691
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      pfam05964
      Location:17401786
      FYRN; F/Y-rich N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30268280..30288371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540408.3XP_006540471.1  histone-lysine N-methyltransferase 2B isoform X1

      UniProtKB/TrEMBL
      F8WJ40
      Related
      ENSMUSP00000006470.8, ENSMUST00000006470.14
      Conserved Domains (11) summary
      cd05493
      Location:13801522
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:24192503
      FYRC; FY-rich domain, C-terminal region
      PHA03307
      Location:18142193
      PHA03307; transcriptional regulator ICP4; Provisional
      PHA03378
      Location:483702
      PHA03378; EBNA-3B; Provisional
      cd15589
      Location:12091255
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:12571306
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:13431399
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:15871691
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      pfam02008
      Location:9631010
      zf-CXXC; CXXC zinc finger domain
      pfam05964
      Location:17391786
      FYRN; F/Y-rich N-terminus
      cd19170
      Location:25682721
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    2. XM_036153503.1XP_036009396.1  histone-lysine N-methyltransferase 2B isoform X3

      Conserved Domains (9) summary
      cd05493
      Location:311453
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:13511435
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:7291153
      PHA03247; large tegument protein UL36; Provisional
      cd15589
      Location:140186
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:188237
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:274330
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:518622
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      cd19170
      Location:15001653
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:670717
      FYRN; F/Y-rich N-terminus
    3. XM_011250733.3XP_011249035.1  histone-lysine N-methyltransferase 2B isoform X2

      Related
      ENSMUSP00000118486.2, ENSMUST00000131002.2
      Conserved Domains (9) summary
      cd05493
      Location:363505
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:14031487
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:7811205
      PHA03247; large tegument protein UL36; Provisional
      cd15589
      Location:192238
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:240289
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:326382
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:570674
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      pfam05964
      Location:722769
      FYRN; F/Y-rich N-terminus
      cd19170
      Location:15521705
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    4. XM_036153504.1XP_036009397.1  histone-lysine N-methyltransferase 2B isoform X3

      Conserved Domains (9) summary
      cd05493
      Location:311453
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:13511435
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:7291153
      PHA03247; large tegument protein UL36; Provisional
      cd15589
      Location:140186
      PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15591
      Location:188237
      PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15593
      Location:274330
      PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
      cd15694
      Location:518622
      ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
      cd19170
      Location:15001653
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:670717
      FYRN; F/Y-rich N-terminus
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