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    Fgfr1op Fgfr1 oncogene partner [ Mus musculus (house mouse) ]

    Gene ID: 75296, updated on 31-Jan-2019

    Summary

    Official Symbol
    Fgfr1opprovided by MGI
    Official Full Name
    Fgfr1 oncogene partnerprovided by MGI
    Primary source
    MGI:MGI:1922546
    See related
    Ensembl:ENSMUSG00000069135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FOP; 4930553O10Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 11.1), CNS E11.5 (RPKM 7.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See Fgfr1op in Genome Data Viewer
    Location:
    17; 17 A1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (8165491..8196477)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (8358401..8389333)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41523 Neighboring gene ribonuclease T2A Neighboring gene chemokine (C-C motif) receptor 6 Neighboring gene predicted gene, 33799 Neighboring gene predicted gene 8465

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90966, MGC117820

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197046.1NP_001183975.1  FGFR1 oncogene partner isoform 1

      See identical proteins and their annotated locations for NP_001183975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB615739, BC108331
      Consensus CDS
      CCDS57045.1
      UniProtKB/Swiss-Prot
      Q66JX5
      Related
      ENSMUSP00000095030.3, ENSMUST00000097419.9
      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain
    2. NM_201230.5NP_957682.1  FGFR1 oncogene partner isoform 2

      See identical proteins and their annotated locations for NP_957682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK016110, AK050389, BC108331
      Consensus CDS
      CCDS28380.1
      UniProtKB/Swiss-Prot
      Q66JX5
      Related
      ENSMUSP00000024636.8, ENSMUST00000024636.14
      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      8165491..8196477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523357.2XP_006523420.1  FGFR1 oncogene partner isoform X3

      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain
    2. XM_006523355.2XP_006523418.1  FGFR1 oncogene partner isoform X1

      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain
    3. XM_006523356.2XP_006523419.1  FGFR1 oncogene partner isoform X2

      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain
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