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    Cep43 centrosomal protein 43 [ Mus musculus (house mouse) ]

    Gene ID: 75296, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cep43provided by MGI
    Official Full Name
    centrosomal protein 43provided by MGI
    Primary source
    MGI:MGI:1922546
    See related
    Ensembl:ENSMUSG00000069135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F; FOP; Fgfr; Fgfr1op; 4930553O10Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 11.1), CNS E11.5 (RPKM 7.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cep43 in Genome Data Viewer
    Location:
    17; 17 A1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (8383976..8415309)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (8165143..8196477)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (8358401..8389333)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41523 Neighboring gene ribonuclease T2A Neighboring gene chemokine (C-C motif) receptor 6 Neighboring gene predicted gene, 33799 Neighboring gene predicted gene 8465

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90966, MGC117820

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centrosomal protein 43
    Names
    Fgfr1 oncogene partner

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197046.1NP_001183975.1  centrosomal protein 43 isoform 1

      See identical proteins and their annotated locations for NP_001183975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB615739, BC108331
      Consensus CDS
      CCDS57045.1
      UniProtKB/Swiss-Prot
      Q66JX5
      Related
      ENSMUSP00000095030.4, ENSMUST00000097419.10
      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain
    2. NM_201230.5NP_957682.1  centrosomal protein 43 isoform 2

      See identical proteins and their annotated locations for NP_957682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK016110, AK050389, BC108331
      Consensus CDS
      CCDS28380.1
      UniProtKB/Swiss-Prot
      Q66JX5
      Related
      ENSMUSP00000024636.9, ENSMUST00000024636.15
      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      8383976..8415309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250124.2XP_030105984.1  centrosomal protein 43 isoform X1

      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain
    2. XM_036160821.1XP_036016714.1  centrosomal protein 43 isoform X4

    3. XM_006523357.3XP_006523420.1  centrosomal protein 43 isoform X2

      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain
    4. XM_030250125.1XP_030105985.1  centrosomal protein 43 isoform X3

      Conserved Domains (1) summary
      pfam09398
      Location:54134
      FOP_dimer; FOP N terminal dimerization domain

    RNA

    1. XR_004939597.1 RNA Sequence

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