Sap25 sin3 associated polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sap25provided by MGI
Official Full Name: sin3 associated polypeptideprovided by MGI
Primary source: MGI:MGI:3802945
See related: Ensembl:ENSMUSG00000079165 AllianceGenome:MGI:3802945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. Orthologous to human SAP25 (Sin3A associated protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 123.8), spleen adult (RPKM 98.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.59 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137639735..137641164)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137641473..137642902)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

BE200288 (e-PCR)
- UniSTS:207897

AI558103 (e-PCR)
- UniSTS:165434

RH124696 (e-PCR)
- UniSTS:161518

Readthrough Gm20605

Readthrough gene: Gm20605, Included gene: Lrch4

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone deacetylase complex subunit SAP25

Names: 25 kDa Sin3-associated polypeptide; mSin3A-binding protein; sin3 corepressor complex subunit SAP25; sin3A-binding protein, SAP25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081962.2 → NP_001075431.2 histone deacetylase complex subunit SAP25

Status: VALIDATED

Source sequence(s)

AM275337, BX517344, CB058897

Consensus CDS

CCDS39336.2

UniProtKB/TrEMBL

E9Q529, H3BLC5

Related

ENSMUSP00000127076.3, ENSMUST00000166099.3

Conserved Domains (1) summary

pfam15476
Location:76 → 258

SAP25; Histone deacetylase complex subunit SAP25