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    KRAS KRAS proto-oncogene, GTPase [ Felis catus (domestic cat) ]

    Gene ID: 751104, updated on 10-Feb-2026
    Official Symbol
    KRAS
    Official Full Name
    KRAS proto-oncogene, GTPase
    Primary source
    VGNC:VGNC:84048
    See related
    Ensembl:ENSFCTG00005013354
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Also known as
    K-RAS
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See KRAS in Genome Data Viewer
    Location:
    chromosome: B4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (58557550..58597919, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (60631473..60670232, complement)

    Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene uncharacterized LOC111561336 Neighboring gene uncharacterized LOC123386555

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. Crozier C, et al. J Comp Pathol, 2016 Jul. PMID 27290644
    2. High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family. Watzinger F, et al. Mamm Genome, 1998 Mar. PMID 9501305
    3. Sequencing and comparative genomic analysis of 1227 Felis catus cDNA sequences enriched for developmental, clinical and nutritional phenotypes. Irizarry KJ, et al. BMC Genomics, 2012 Jan 18. PMID 22257742, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KRAS mutations do not play a critical role in feline or canine pancreatic acinar cell carcinomas
      Title: KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma.
    Submit: New GeneRIF Correction

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    GTPase KRas
    Names
    ras p21

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      58557550..58597919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023256853.2 → XP_023112621.1  GTPase KRas isoform X2

      UniProtKB/TrEMBL
      A0ABI7XVE0
      Related
      ENSFCTP00005026495.1, ENSFCTT00005037943.1
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. XM_045061560.1 → XP_044917495.1  GTPase KRas isoform X3

      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    3. XM_045061559.1 → XP_044917494.1  GTPase KRas isoform X1

      UniProtKB/TrEMBL
      A0ABI7XVY9
      Related
      ENSFCTP00005026576.1, ENSFCTT00005038045.1
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials