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    Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [ Mus musculus (house mouse) ]

    Gene ID: 74838, updated on 24-Jan-2023

    Summary

    Official Symbol
    Naa15provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 15, NatA auxiliary subunitprovided by MGI
    Primary source
    MGI:MGI:1922088
    See related
    Ensembl:ENSMUSG00000063273 AllianceGenome:MGI:1922088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Narg1; mNAT1; ASTBDN; Tbdn-1; 6330400I15; 5730450D16Rik
    Summary
    Enables N-acetyltransferase activity. Predicted to be involved in several processes, including N-terminal peptidyl-methionine acetylation; positive regulation of transcription, DNA-templated; and protein stabilization. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in cytoplasm. Is expressed in several structures, including brain; cornea endothelium; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 15.4), placenta adult (RPKM 10.3) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Naa15 in Genome Data Viewer
    Location:
    3; 3 C
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51323437..51383406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51416016..51475985)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9442 Neighboring gene NADH:ubiquinone oxidoreductase subunit C1 Neighboring gene predicted gene, 50622 Neighboring gene RAB33B, member RAS oncogene family Neighboring gene predicted gene, 36008

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29428

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
     
    contributes_to ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NatA complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    N-alpha-acetyltransferase 15, NatA auxiliary subunit
    Names
    N-terminal acetyltransferase 1
    N-terminal aceyltransferase 1
    NMDA receptor-regulated gene 1
    NMDA receptor-regulated protein 1
    protein tubedown-1
    tubedown

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053089.3NP_444319.3  N-alpha-acetyltransferase 15, NatA auxiliary subunit

      See identical proteins and their annotated locations for NP_444319.3

      Status: VALIDATED

      Source sequence(s)
      AB221683, AC102860, BQ887090, CA327064, CX241349
      Consensus CDS
      CCDS17340.1
      UniProtKB/TrEMBL
      A0A8C6H237, G3X8Y3
      Related
      ENSMUSP00000029303.8, ENSMUST00000029303.13
      Conserved Domains (3) summary
      sd00006
      Location:82108
      TPR; TPR repeat [structural motif]
      pfam12569
      Location:187698
      NARP1; NMDA receptor-regulated protein 1
      pfam13414
      Location:82145
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51323437..51383406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)