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    Wipi2 WD repeat domain, phosphoinositide interacting 2 [ Mus musculus (house mouse) ]

    Gene ID: 74781, updated on 12-Aug-2018

    Summary

    Official Symbol
    Wipi2provided by MGI
    Official Full Name
    WD repeat domain, phosphoinositide interacting 2provided by MGI
    Primary source
    MGI:MGI:1923831
    See related
    Ensembl:ENSMUSG00000029578 Vega:OTTMUSG00000026064
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110018O08Rik; 2510001I10Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 25.2), adrenal adult (RPKM 22.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Wipi2 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (142629535..142669672)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (143105538..143145326)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene predicted gene, 31274 Neighboring gene predicted gene, 40352 Neighboring gene solute carrier family 29 (nucleoside transporters), member 4 Neighboring gene trinucleotide repeat containing 18 Neighboring gene predicted gene, 31365

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - other, organism-specific biosystem (from KEGG)
      Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - other, conserved biosystem (from KEGG)
      Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein lipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein lipidation involved in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to phagophore assembly site IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    xenophagy IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
     
    phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagophore assembly site membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WD repeat domain phosphoinositide-interacting protein 2
    Names
    WIPI-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178398.4NP_848485.1  WD repeat domain phosphoinositide-interacting protein 2

      See identical proteins and their annotated locations for NP_848485.1

      Status: PROVISIONAL

      Source sequence(s)
      AC105987, AC158310
      Consensus CDS
      CCDS19828.1
      UniProtKB/Swiss-Prot
      Q80W47
      Related
      ENSMUSP00000045201.9, OTTMUSP00000031934, ENSMUST00000036872.15, OTTMUST00000064336
      Conserved Domains (2) summary
      COG2319
      Location:21272
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:143182
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      142629535..142669672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504752.3XP_006504815.1  WD repeat domain phosphoinositide-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006504815.1

      Conserved Domains (3) summary
      COG2319
      Location:2216
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1756
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:25219
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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