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    Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 74763, updated on 23-Jun-2021

    Summary

    Official Symbol
    Naa60provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 60, NatF catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1922013
    See related
    Ensembl:ENSMUSG00000005982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nat; HAT4; NatF; Nat15; AI315146; 1200013P24Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 39.1), mammary gland adult (RPKM 28.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Naa60 in Genome Data Viewer
    Location:
    16; 16 A1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3690365..3722645)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3872496..3904781)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (3884619..3904781)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor 15 Neighboring gene zinc finger protein 174 Neighboring gene zinc finger protein 597 Neighboring gene predicted gene, 41410 Neighboring gene RIKEN cDNA 1700037C18 gene Neighboring gene clusterin associated protein 1 Neighboring gene prothymosin alpha-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables H4 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in N-terminal peptidyl-methionine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    N-alpha-acetyltransferase 60
    Names
    N-acetyltransferase 15 (GCN5-related, putative)
    N-alpha-acetyltransferase F
    histone acetyltransferase type B protein 4
    natF catalytic subunit
    NP_001277618.1
    NP_083366.1
    XP_006522742.1
    XP_006522743.1
    XP_017172644.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290689.1NP_001277618.1  N-alpha-acetyltransferase 60 isoform 2

      See identical proteins and their annotated locations for NP_001277618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC129021, AI035720, AI448494, AK004750
      Consensus CDS
      CCDS70676.1
      UniProtKB/Swiss-Prot
      Q9DBU2
      UniProtKB/TrEMBL
      H3BIY0
      Related
      ENSMUSP00000134768.2, ENSMUST00000176625.8
      Conserved Domains (2) summary
      pfam00583
      Location:1290
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:74138
      TIM; TIM-like beta/alpha barrel domains
    2. NM_029090.3NP_083366.1  N-alpha-acetyltransferase 60 isoform 1

      See identical proteins and their annotated locations for NP_083366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC129021, BG147816, BI739241, BY255312, CF540715
      Consensus CDS
      CCDS37239.1
      UniProtKB/Swiss-Prot
      Q9DBU2
      Related
      ENSMUSP00000140031.2, ENSMUST00000186375.8
      Conserved Domains (2) summary
      pfam00583
      Location:23155
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:139203
      TIM; TIM-like beta/alpha barrel domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3690365..3722645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522680.4XP_006522743.1  N-alpha-acetyltransferase 60 isoform X1

      See identical proteins and their annotated locations for XP_006522743.1

      UniProtKB/Swiss-Prot
      Q9DBU2
      Related
      ENSMUSP00000135206.2, ENSMUST00000150655.3
      Conserved Domains (2) summary
      pfam00583
      Location:23155
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:139203
      TIM; TIM-like beta/alpha barrel domains
    2. XM_017317155.2XP_017172644.1  N-alpha-acetyltransferase 60 isoform X2

      UniProtKB/TrEMBL
      H3BJZ6
      Related
      ENSMUSP00000135188.2, ENSMUST00000143537.9
      Conserved Domains (1) summary
      cl17182
      Location:23113
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    3. XM_006522679.3XP_006522742.1  N-alpha-acetyltransferase 60 isoform X1

      See identical proteins and their annotated locations for XP_006522742.1

      UniProtKB/Swiss-Prot
      Q9DBU2
      Conserved Domains (2) summary
      pfam00583
      Location:23155
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:139203
      TIM; TIM-like beta/alpha barrel domains
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