Format

Send to:

Choose Destination
    • Showing Current items.

    Ddit4 DNA-damage-inducible transcript 4 [ Mus musculus (house mouse) ]

    Gene ID: 74747, updated on 5-Mar-2019

    Summary

    Official Symbol
    Ddit4provided by MGI
    Official Full Name
    DNA-damage-inducible transcript 4provided by MGI
    Primary source
    MGI:MGI:1921997
    See related
    Ensembl:ENSMUSG00000020108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dig2; REDD1; Rtp801; AA415483; 5830413E08Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 71.7), adrenal adult (RPKM 65.1) and 26 other tissues See more
    Orthologs

    Genomic context

    See Ddit4 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (59949675..59951770, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (59412423..59414518, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 Neighboring gene predicted gene, 46226 Neighboring gene predicted gene, 40673 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 Neighboring gene microRNA 6906

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Metabolic Genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    brain development ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA damage-inducible transcript 4 protein
    Names
    HIF-1 responsive RTP801
    HIF-1 responsive protein RTP801
    REDD-1
    dexamethasone-induced gene 2 protein
    protein regulated in development and DNA damage response 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029083.2NP_083359.1  DNA damage-inducible transcript 4 protein

      See identical proteins and their annotated locations for NP_083359.1

      Status: PROVISIONAL

      Source sequence(s)
      AK017926
      Consensus CDS
      CCDS23868.1
      UniProtKB/Swiss-Prot
      Q9D3F7
      UniProtKB/TrEMBL
      B7ZNP9
      Related
      ENSMUSP00000020308.3, ENSMUST00000020308.4
      Conserved Domains (1) summary
      pfam07809
      Location:101220
      RTP801_C; RTP801 C-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      59949675..59951770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center