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    C2cd5 C2 calcium-dependent domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 74741, updated on 31-Jan-2019

    Summary

    Official Symbol
    C2cd5provided by MGI
    Official Full Name
    C2 calcium-dependent domain containing 5provided by MGI
    Primary source
    MGI:MGI:1921991
    See related
    Ensembl:ENSMUSG00000030279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDP138; 5730419I09Rik; C030008B15Rik
    Expression
    Broad expression in CNS E18 (RPKM 8.8), CNS E14 (RPKM 8.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See C2cd5 in Genome Data Viewer
    Location:
    6; 6 G3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (143010920..143100152, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142959440..143048627, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 7457 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Neighboring gene predicted gene 7468 Neighboring gene predicted gene, 31108 Neighboring gene predicted gene, 38921 Neighboring gene ethanolamine kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • Kiaa0528

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor signaling pathway via phosphatidylinositol 3-kinase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C2 domain-containing protein 5
    Names
    138 kDa C2 domain-containing phosphoprotein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109688.2NP_001103158.1  C2 domain-containing protein 5 isoform 3

      See identical proteins and their annotated locations for NP_001103158.1

      Status: VALIDATED

      Source sequence(s)
      AC127354, AK141590, AK143732, AK162114, AK163233, AU022314, BC053913
      Consensus CDS
      CCDS51953.1
      UniProtKB/Swiss-Prot
      Q7TPS5
      UniProtKB/TrEMBL
      Q3TSE2
      Related
      ENSMUSP00000084758.4, ENSMUST00000087485.6
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    2. NM_001286578.1NP_001273507.1  C2 domain-containing protein 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC127354, AK029825, AK143732, AK162114, AK163233, AU022314, BC053913
      UniProtKB/Swiss-Prot
      Q7TPS5
      UniProtKB/TrEMBL
      Q3TSE2
    3. NM_001362113.1NP_001349042.1  C2 domain-containing protein 5 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AC122797, AC127354
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    4. NM_001362114.1NP_001349043.1  C2 domain-containing protein 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122797, AC127354
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    5. NM_001362115.1NP_001349044.1  C2 domain-containing protein 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122797, AC127354
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    6. NM_001362116.1NP_001349045.1  C2 domain-containing protein 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122797, AC127354
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    7. NM_001362117.1NP_001349046.1  C2 domain-containing protein 5 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122797, AC127354
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    8. NM_001362118.1NP_001349047.1  C2 domain-containing protein 5 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC122797, AC127354
    9. NM_029081.3NP_083357.2  C2 domain-containing protein 5 isoform 1

      See identical proteins and their annotated locations for NP_083357.2

      Status: VALIDATED

      Source sequence(s)
      AC127354, AK029825, AK143732, AK162114, AK163233, AU022314, BC053913
      Consensus CDS
      CCDS51952.1
      UniProtKB/Swiss-Prot
      Q7TPS5
      UniProtKB/TrEMBL
      Q3TSE2
      Related
      ENSMUSP00000145373.1, ENSMUST00000203187.2
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    10. NM_029897.2NP_084173.1  C2 domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_084173.1

      Status: VALIDATED

      Source sequence(s)
      AC127354, AK143732, AK162114, AU022314, BC053913
      Consensus CDS
      CCDS51951.1
      UniProtKB/Swiss-Prot
      Q7TPS5
      UniProtKB/TrEMBL
      E9Q026, Q3TSE2
      Related
      ENSMUSP00000127834.1, ENSMUST00000171349.7
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      143010920..143100152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507003.3XP_006507066.1  C2 domain-containing protein 5 isoform X7

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    2. XM_017321797.1XP_017177286.1  C2 domain-containing protein 5 isoform X3

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    3. XM_017321809.1XP_017177298.1  C2 domain-containing protein 5 isoform X16

    4. XM_017321806.1XP_017177295.1  C2 domain-containing protein 5 isoform X13

    5. XM_017321799.1XP_017177288.1  C2 domain-containing protein 5 isoform X5

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    6. XM_017321804.1XP_017177293.1  C2 domain-containing protein 5 isoform X11

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    7. XM_017321801.1XP_017177290.1  C2 domain-containing protein 5 isoform X8

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    8. XM_006506997.3XP_006507060.1  C2 domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006507060.1

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    9. XM_017321802.1XP_017177291.1  C2 domain-containing protein 5 isoform X9

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    10. XM_017321805.1XP_017177294.1  C2 domain-containing protein 5 isoform X12

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    11. XM_017321798.1XP_017177287.1  C2 domain-containing protein 5 isoform X4

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    12. XM_017321808.1XP_017177297.1  C2 domain-containing protein 5 isoform X15

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    13. XM_017321800.1XP_017177289.1  C2 domain-containing protein 5 isoform X6

      UniProtKB/TrEMBL
      A0A0N4SW93
      Related
      ENSMUSP00000145425.1, ENSMUST00000203673.2
      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    14. XM_017321807.1XP_017177296.1  C2 domain-containing protein 5 isoform X14

    15. XM_017321803.1XP_017177292.1  C2 domain-containing protein 5 isoform X10

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    16. XM_017321796.1XP_017177285.1  C2 domain-containing protein 5 isoform X2

      Conserved Domains (1) summary
      cd08688
      Location:5114
      C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    17. XM_017321811.1XP_017177300.1  C2 domain-containing protein 5 isoform X20

    18. XM_006507007.1XP_006507070.1  C2 domain-containing protein 5 isoform X17

    19. XM_006507009.3XP_006507072.1  C2 domain-containing protein 5 isoform X18

    20. XM_017321810.1XP_017177299.1  C2 domain-containing protein 5 isoform X19

    21. XM_017321812.1XP_017177301.1  C2 domain-containing protein 5 isoform X21

    22. XM_017321813.1XP_017177302.1  C2 domain-containing protein 5 isoform X22

    RNA

    1. XR_001785181.1 RNA Sequence

      Related
      ENSMUST00000205119.2
    2. XR_001785180.1 RNA Sequence

    3. XR_001785182.1 RNA Sequence

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