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    WNT5A Wnt family member 5A [ Homo sapiens (human) ]

    Gene ID: 7474, updated on 13-Jun-2024

    Summary

    Official Symbol
    WNT5Aprovided by HGNC
    Official Full Name
    Wnt family member 5Aprovided by HGNC
    Primary source
    HGNC:HGNC:12784
    See related
    Ensembl:ENSG00000114251 MIM:164975; AllianceGenome:HGNC:12784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hWNT5A
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in urinary bladder (RPKM 9.1), endometrium (RPKM 7.3) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See WNT5A in Genome Data Viewer
    Location:
    3p14.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (55465715..55505263, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (55499921..55539460, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (55499743..55521334, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906243 Neighboring gene long intergenic non-protein coding RNA 2030 Neighboring gene uncharacterized LOC124909383 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:55508124-55508358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:55515943-55516553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:55522958-55523468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:55523469-55523980 Neighboring gene VISTA enhancer hs1472 Neighboring gene NANOG hESC enhancer GRCh37_chr3:55545884-55546385 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:55553529-55554030 Neighboring gene WNT5A antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:55589475-55589976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:55605047-55605674 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:55605675-55606302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:55610793-55611315 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:55612193-55612392 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:55615025-55615237 Neighboring gene uncharacterized LOC105377100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19976 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:55649046-55649821 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:55649822-55650596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:55681397-55681910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:55681911-55682424 Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19978 Neighboring gene ERC2 intronic transcript 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of WNT5a in human neural stem cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemoattractant activity involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables frizzled binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity IC
    Inferred by Curator
    more info
    PubMed 
    enables receptor tyrosine kinase-like orphan receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Wnt signaling pathway, calcium modulating pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway, calcium modulating pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Wnt signaling pathway, planar cell polarity pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in anterior/posterior axis specification, embryo IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in atrial septum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon extension involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to type II interferon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cervix development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemoattraction of serotonergic neuron axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chemorepulsion of dopaminergic neuron axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cochlea morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in convergent extension involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in convergent extension involved in organogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell proliferation involved in mammary gland duct elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in establishment of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of planar polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in face development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hindgut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hypophysis morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inhibitory synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in keratinocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lateral sprouting involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lens development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage derived foam cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mammary gland branching involved in thelarche IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in melanocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal-epithelial cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesodermal to mesenchymal transition involved in gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbrain dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in midgut development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of axon extension involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell proliferation in midbrain NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of melanin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mesenchymal cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of prostatic bud formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in non-canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in notochord morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in olfactory bulb interneuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in optic cup formation involved in camera-type eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in paraxial mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in cardiac right atrium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in gastrula mediolateral intercalation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in pericardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in ventricular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of hematopoietic stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of non-canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein kinase C activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase C signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to synapse TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of timing of anagen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-anal tail morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postsynapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in primary heart field specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in primitive streak formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in secondary heart field specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in secondary palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type B pancreatic cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urinary bladder development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein Wnt-5a
    Names
    WNT-5A protein
    epididymis secretory sperm binding protein
    wingless-type MMTV integration site family, member 5A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031992.2 RefSeqGene

      Range
      22957..44548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256105.1NP_001243034.1  protein Wnt-5a isoform 2 precursor

      See identical proteins and their annotated locations for NP_001243034.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.
      Source sequence(s)
      AC121764, AK290869, BU742635, DB224740
      Consensus CDS
      CCDS58835.1
      UniProtKB/TrEMBL
      Q6DK41
      Related
      ENSP00000420104.1, ENST00000497027.5
      Conserved Domains (1) summary
      cd19347
      Location:54365
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    2. NM_001377271.1NP_001364200.1  protein Wnt-5a isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC121764
      Consensus CDS
      CCDS58835.1
      UniProtKB/TrEMBL
      Q6DK41
      Conserved Domains (1) summary
      cd19347
      Location:54365
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    3. NM_001377272.1NP_001364201.1  protein Wnt-5a isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC121764
      Consensus CDS
      CCDS58835.1
      UniProtKB/TrEMBL
      Q6DK41
      Conserved Domains (1) summary
      cd19347
      Location:54365
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    4. NM_003392.7NP_003383.4  protein Wnt-5a isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC121764, AK090582, BC064694, BU742635
      Consensus CDS
      CCDS46850.1
      UniProtKB/Swiss-Prot
      A8K4A4, P41221, Q6P278
      UniProtKB/TrEMBL
      A0A384N611, Q6DK41
      Related
      ENSP00000264634.4, ENST00000264634.9
      Conserved Domains (1) summary
      cd19347
      Location:69380
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      55465715..55505263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448855.1XP_047304811.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    2. XM_047448853.1XP_047304809.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    3. XM_047448857.1XP_047304813.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    4. XM_047448854.1XP_047304810.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    5. XM_047448859.1XP_047304815.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    6. XM_011534086.3XP_011532388.1  protein Wnt-5a isoform X1

      See identical proteins and their annotated locations for XP_011532388.1

      UniProtKB/TrEMBL
      Q6DK41
      Conserved Domains (1) summary
      cd19347
      Location:54365
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    7. XM_017007128.2XP_016862617.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
      Conserved Domains (1) summary
      cd19347
      Location:54365
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    8. XM_047448858.1XP_047304814.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    9. XM_047448862.1XP_047304818.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    10. XM_047448861.1XP_047304817.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    11. XM_047448856.1XP_047304812.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    12. XM_047448860.1XP_047304816.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    13. XM_047448852.1XP_047304808.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    14. XM_017007127.2XP_016862616.1  protein Wnt-5a isoform X2

      UniProtKB/TrEMBL
      Q6DK41
    15. XM_011534088.3XP_011532390.1  protein Wnt-5a isoform X1

      See identical proteins and their annotated locations for XP_011532390.1

      UniProtKB/TrEMBL
      Q6DK41
      Conserved Domains (1) summary
      cd19347
      Location:54365
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    16. XM_011534089.2XP_011532391.1  protein Wnt-5a isoform X1

      See identical proteins and their annotated locations for XP_011532391.1

      UniProtKB/TrEMBL
      Q6DK41
      Conserved Domains (1) summary
      cd19347
      Location:54365
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      55499921..55539460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347752.1XP_054203727.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    2. XM_054347756.1XP_054203731.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    3. XM_054347755.1XP_054203730.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    4. XM_054347753.1XP_054203728.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    5. XM_054347754.1XP_054203729.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    6. XM_054347750.1XP_054203725.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    7. XM_054347751.1XP_054203726.1  protein Wnt-5a isoform X2

      UniProtKB/TrEMBL
      Q6DK41
    8. XM_054347757.1XP_054203732.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41
    9. XM_054347758.1XP_054203733.1  protein Wnt-5a isoform X1

      UniProtKB/TrEMBL
      Q6DK41