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    Brme1 break repair meiotic recombinase recruitment factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74666, updated on 11-Jul-2021

    Summary

    Official Symbol
    Brme1provided by MGI
    Official Full Name
    break repair meiotic recombinase recruitment factor 1provided by MGI
    Primary source
    MGI:MGI:1921916
    See related
    Ensembl:ENSMUSG00000008129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRM; Meiok21; 4930432K21Rik
    Expression
    Biased expression in testis adult (RPKM 23.7) and ovary adult (RPKM 2.1) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Brme1 in Genome Data Viewer
    Location:
    8; 8 C2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84874637..84899226)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84148008..84172597)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (86671937..86696496)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39210 Neighboring gene DDB1 and CUL4 associated factor 15 Neighboring gene podocan-like 1 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene nanos C2HC-type zinc finger 3 Neighboring gene microRNA 181d Neighboring gene microRNA 181c

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair involved in meiotic recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiosis I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    break repair meiotic recombinase recruitment factor 1; uncharacterized protein C19orf57 homolog
    Names
    BRCA2 and MEILB2-associating protein 1
    meiotic recombination modulator

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163752.1NP_001157224.1  break repair meiotic recombinase recruitment factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001157224.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC159266, AK015293, BQ560290, BY296159
      Consensus CDS
      CCDS52617.1
      UniProtKB/Swiss-Prot
      Q6DIA7
      UniProtKB/TrEMBL
      A0A0R4J144
      Related
      ENSMUSP00000091067.5, ENSMUST00000093375.5
      Conserved Domains (1) summary
      pfam15710
      Location:1565
      DUF4671; Domain of unknown function (DUF4671)
    2. NM_029045.2NP_083321.2  break repair meiotic recombinase recruitment factor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159266, AK015293, BC075658, BQ560290, BY296159
      Consensus CDS
      CCDS52616.1
      UniProtKB/Swiss-Prot
      Q6DIA7
      UniProtKB/TrEMBL
      E9QNR8
      Related
      ENSMUSP00000113651.2, ENSMUST00000118856.8
      Conserved Domains (1) summary
      pfam15710
      Location:1600
      DUF4671; Domain of unknown function (DUF4671)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84874637..84899226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243821.1XP_030099681.1  uncharacterized protein C19orf57 homolog isoform X1

      Conserved Domains (1) summary
      pfam15710
      Location:1570
      DUF4671; Domain of unknown function (DUF4671)
    2. XM_006531445.4XP_006531508.1  uncharacterized protein C19orf57 homolog isoform X1

      See identical proteins and their annotated locations for XP_006531508.1

      Conserved Domains (1) summary
      pfam15710
      Location:1570
      DUF4671; Domain of unknown function (DUF4671)
    3. XM_030243822.1XP_030099682.1  uncharacterized protein C19orf57 homolog isoform X2

      Conserved Domains (1) summary
      pfam15710
      Location:4535
      DUF4671; Domain of unknown function (DUF4671)
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