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    Zkscan1 zinc finger with KRAB and SCAN domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 74570, updated on 23-Jun-2021

    Summary

    Official Symbol
    Zkscan1provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 1provided by MGI
    Primary source
    MGI:MGI:1921820
    See related
    Ensembl:ENSMUSG00000029729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KOX1; KOX18; C87323; PHZ-37; ZNF139; AI646829; AI788588; 5930429A01Rik; 9130423L19Rik; 9230118B16Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.8), whole brain E14.5 (RPKM 6.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Zkscan1 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138083312..138106084)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138085050..138107822)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (138526312..138549050)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sperm motility kinase 3B Neighboring gene sperm motility kinase 3C Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene zinc finger protein 113

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC63357

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein with KRAB and SCAN domains 1
    Names
    zinc finger protein 36 (KOX 18)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029869.1NP_084145.1  zinc finger protein with KRAB and SCAN domains 1 isoform 2

      See identical proteins and their annotated locations for NP_084145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
      Source sequence(s)
      BC052441, BY282109, CAAA01224679
      Consensus CDS
      CCDS19788.1
      UniProtKB/Swiss-Prot
      Q8BGS3
      Related
      ENSMUSP00000106588.2, ENSMUST00000110963.8
      Conserved Domains (3) summary
      smart00431
      Location:52162
      SCAN; leucine rich region
      COG5048
      Location:281462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332352
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_133906.4NP_598667.2  zinc finger protein with KRAB and SCAN domains 1 isoform 1

      See identical proteins and their annotated locations for NP_598667.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK036807, AK054323, BY282109, CAAA01224679
      Consensus CDS
      CCDS19789.1
      UniProtKB/Swiss-Prot
      Q8BGS3
      Related
      ENSMUSP00000019660.5, ENSMUST00000019660.11
      Conserved Domains (7) summary
      smart00431
      Location:52162
      SCAN; leucine rich region
      COG5048
      Location:354535
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:405425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:375397
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:225263
      KRAB; KRAB box
      pfam02023
      Location:52129
      SCAN; SCAN domain
      pfam13465
      Location:473498
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138083312..138106084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504628.4XP_006504691.1  zinc finger protein with KRAB and SCAN domains 1 isoform X1

      See identical proteins and their annotated locations for XP_006504691.1

      UniProtKB/Swiss-Prot
      Q8BGS3
      Related
      ENSMUSP00000068480.6, ENSMUST00000066617.12
      Conserved Domains (3) summary
      smart00431
      Location:52162
      SCAN; leucine rich region
      COG5048
      Location:281462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332352
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011240958.3XP_011239260.1  zinc finger protein with KRAB and SCAN domains 1 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:143324
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:194214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1354
      KRAB; KRAB box
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