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    Ttc17 tetratricopeptide repeat domain 17 [ Mus musculus (house mouse) ]

    Gene ID: 74569, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ttc17provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 17provided by MGI
    Primary source
    MGI:MGI:1921819
    See related
    Ensembl:ENSMUSG00000027194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D2Bwg1005e; 9130020K17Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.7), colon adult (RPKM 4.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ttc17 in Genome Data Viewer
    Location:
    2 E1; 2 51.69 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (94131111..94237034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (94300766..94406710, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (94140923..94246846, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MIR670 host gene (non-protein coding) Neighboring gene microRNA 129-2 Neighboring gene microRNA 129b Neighboring gene microRNA 670 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 1 Neighboring gene RIKEN cDNA 2810002D19 gene Neighboring gene apoptosis inhibitor 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 17
    Names
    TPR repeat protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355690.1NP_001342619.1  tetratricopeptide repeat protein 17 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL672251, AL683878
      Consensus CDS
      CCDS89523.1
      Related
      ENSMUSP00000106868.3, ENSMUST00000111237.9
      Conserved Domains (5) summary
      COG0457
      Location:9791136
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:621647
      TPR; TPR repeat [structural motif]
      cd16269
      Location:379390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329410
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26002
      Location:573718
      TPR_11; TPR repeat
    2. NM_001355691.1NP_001342620.1  tetratricopeptide repeat protein 17 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL672251, AL683878
      Conserved Domains (4) summary
      sd00006
      Location:621647
      TPR; TPR repeat [structural motif]
      cd16269
      Location:379390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329410
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl26002
      Location:573718
      TPR_11; TPR repeat
    3. NM_183106.2NP_898929.2  tetratricopeptide repeat protein 17 isoform 1

      See identical proteins and their annotated locations for NP_898929.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI851013, AK018641, AK038364, AL683878, BE626951, BY358550, CA328748, CF536785, CJ180754
      Consensus CDS
      CCDS38185.1
      UniProtKB/Swiss-Prot
      E9PVB5
      UniProtKB/TrEMBL
      Q8C1H7
      Related
      ENSMUSP00000106869.2, ENSMUST00000111238.8
      Conserved Domains (6) summary
      smart00028
      Location:689718
      TPR; Tetratricopeptide repeats
      sd00006
      Location:621647
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:11451175
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:11111173
      TPR_11; TPR repeat
      cd16269
      Location:379390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329410
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      94131111..94237034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500310.5XP_006500373.1  tetratricopeptide repeat protein 17 isoform X1

      Conserved Domains (5) summary
      COG0457
      Location:9951152
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR02917
      Location:532677
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:580606
      TPR; TPR repeat [structural motif]
      cd16269
      Location:338349
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:288369
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. XM_006500312.5XP_006500375.1  tetratricopeptide repeat protein 17 isoform X2

      UniProtKB/TrEMBL
      A2AFY7
      Related
      ENSMUSP00000092395.5, ENSMUST00000094801.5
      Conserved Domains (5) summary
      TIGR02917
      Location:573718
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:621647
      TPR; TPR repeat [structural motif]
      cd16269
      Location:379390
      GBP_C; coiled coil [structural motif]
      pfam00515
      Location:297328
      TPR_1; Tetratricopeptide repeat
      cl20817
      Location:329410
      GBP_C; Guanylate-binding protein, C-terminal domain
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