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    Mau2 MAU2 sister chromatid cohesion factor [ Mus musculus (house mouse) ]

    Gene ID: 74549, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mau2provided by MGI
    Official Full Name
    MAU2 sister chromatid cohesion factorprovided by MGI
    Primary source
    MGI:MGI:1921799
    See related
    Ensembl:ENSMUSG00000031858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mau-2; C77863; C79014; Gm7730; EG665649; mKIAA0892; 9130404D08Rik; A930019L04Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 37.4), ovary adult (RPKM 33.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mau2 in Genome Data Viewer
    Location:
    8; 8 B3.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (70016123..70042734, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (72540022..72566633, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene GATA zinc finger domain containing 2A Neighboring gene testis-specific serine kinase 6 Neighboring gene SURP and G patch domain containing 1 Neighboring gene transmembrane 6 superfamily member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0892, MGC159271

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    cohesin loading ISO
    Inferred from Sequence Orthology
    more info
     
    maintenance of mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    SMC loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMC loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    Scc2-Scc4 cohesin loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MAU2 chromatid cohesion factor homolog
    Names
    Scc4-like protein
    cohesin loading complex subunit SCC4 homolog
    protein MAU-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167939.1NP_001161411.1  MAU2 chromatid cohesion factor homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK039196, AK081967, AK220358
      Consensus CDS
      CCDS85550.1
      UniProtKB/Swiss-Prot
      Q9D2X5
      UniProtKB/TrEMBL
      A0A1D5RLR7
      Related
      ENSMUSP00000148479.1, ENSMUST00000212308.1
      Conserved Domains (3) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30576
      Cohesin_load; Cohesin loading factor
      pfam14559
      Location:86157
      TPR_19; Tetratricopeptide repeat
    2. NM_028993.4NP_083269.4  MAU2 chromatid cohesion factor homolog isoform 2

      See identical proteins and their annotated locations for NP_083269.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK039196, AK081967, AK220358
      Consensus CDS
      CCDS40364.1
      UniProtKB/Swiss-Prot
      Q9D2X5
      Related
      ENSMUSP00000054763.6, ENSMUST00000050561.12
      Conserved Domains (2) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30575
      Cohesin_load; Cohesin loading factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      70016123..70042734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      70010421..70011039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509776.3XP_006509839.1  MAU2 chromatid cohesion factor homolog isoform X1

      See identical proteins and their annotated locations for XP_006509839.1

      UniProtKB/Swiss-Prot
      Q9D2X5
      Related
      ENSMUSP00000148601.1, ENSMUST00000212451.1
      Conserved Domains (2) summary
      sd00006
      Location:71100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30576
      Cohesin_load; Cohesin loading factor

    RNA

    1. XR_870466.2 RNA Sequence

      Related
      ENSMUST00000212845.1
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