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    Gzf1 GDNF-inducible zinc finger protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 74533, updated on 2-Oct-2018

    Summary

    Official Symbol
    Gzf1provided by MGI
    Official Full Name
    GDNF-inducible zinc finger protein 1provided by MGI
    Primary source
    MGI:MGI:1921783
    See related
    Ensembl:ENSMUSG00000027439 Vega:OTTMUSG00000015714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGZF1; Zfp336; 8430437G08Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 6.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gzf1 in Genome Data Viewer
    Location:
    2; 2 G3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (148679385..148692949)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (148506856..148518685)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46770 Neighboring gene uncharacterized LOC108168731 Neighboring gene predicted gene, 46771 Neighboring gene NTF2-related export protein 1 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein beta Neighboring gene cystatin-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    GDNF-inducible zinc finger protein 1
    Names
    zinc finger protein 336

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355689.1NP_001342618.1  GDNF-inducible zinc finger protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL928638
      Conserved Domains (5) summary
      COG5048
      Location:410538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21133
      BTB; BTB/POZ domain
      pfam13465
      Location:531556
      zf-H2C2_2; Zinc-finger double domain
    2. NM_028986.3NP_083262.1  GDNF-inducible zinc finger protein 1

      See identical proteins and their annotated locations for NP_083262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK052820, BC096015, BY123697
      Consensus CDS
      CCDS16841.1
      UniProtKB/Swiss-Prot
      Q4VBD9
      Related
      ENSMUSP00000028928.7, OTTMUSP00000016724, ENSMUST00000028928.7, OTTMUST00000037333
      Conserved Domains (5) summary
      COG5048
      Location:410538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21133
      BTB; BTB/POZ domain
      pfam13465
      Location:531556
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      148679385..148692949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239819.1XP_011238121.1  GDNF-inducible zinc finger protein 1 isoform X2

      Conserved Domains (4) summary
      smart00225
      Location:32125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:348369
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21125
      BTB; BTB/POZ domain
      pfam13465
      Location:419444
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006500305.3XP_006500368.1  GDNF-inducible zinc finger protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006500368.1

      UniProtKB/Swiss-Prot
      Q4VBD9
      Conserved Domains (5) summary
      COG5048
      Location:410538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21133
      BTB; BTB/POZ domain
      pfam13465
      Location:531556
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006500304.3XP_006500367.1  GDNF-inducible zinc finger protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBD9
      Conserved Domains (5) summary
      COG5048
      Location:410538
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:519539
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21133
      BTB; BTB/POZ domain
      pfam13465
      Location:531556
      zf-H2C2_2; Zinc-finger double domain
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