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    Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [ Mus musculus (house mouse) ]

    Gene ID: 74493, updated on 16-Nov-2018

    Summary

    Official Symbol
    Tnks2provided by MGI
    Official Full Name
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2provided by MGI
    Primary source
    MGI:MGI:1921743
    See related
    Ensembl:ENSMUSG00000024811 Vega:OTTMUSG00000035920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD6; Tank2; TNKS-2; AA517131; AI662480; 5430432P15Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 24.7), CNS E11.5 (RPKM 20.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tnks2 in Genome Data Viewer
    Location:
    19; 19 C2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (36834230..36893477)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (36908722..36967967)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 2 Neighboring gene Hectd2, opposite strand Neighboring gene protein phosphatase 1, regulatory subunit 3C Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    protein ADP-ribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein auto-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tankyrase-2
    Names
    ADP-ribosyltransferase diphtheria toxin-like 6
    TRF1-interacting ankyrin-related ADP-ribose polymerase 2
    tankyrase II
    tankyrase-like protein
    tankyrase-related protein
    NP_001157107.1
    XP_006527471.1
    XP_006527472.1
    XP_011245684.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163635.1NP_001157107.1  tankyrase-2

      See identical proteins and their annotated locations for NP_001157107.1

      Status: VALIDATED

      Source sequence(s)
      AK047094, AK149368, AK163335, BC063101, BY710137, CN531910
      Consensus CDS
      CCDS50426.1
      UniProtKB/Swiss-Prot
      Q3UES3
      Related
      ENSMUSP00000025729.5, OTTMUSP00000050843, ENSMUST00000025729.11, OTTMUST00000092127
      Conserved Domains (8) summary
      cd09524
      Location:871936
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      smart00454
      Location:877933
      SAM; Sterile alpha motif
      cd00204
      Location:518643
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:9381160
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      pfam00644
      Location:9521155
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam12796
      Location:530622
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:2878
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:528556
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      36834230..36893477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527409.3XP_006527472.1  tankyrase-2 isoform X2

      Conserved Domains (9) summary
      cd09524
      Location:808873
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      smart00454
      Location:814870
      SAM; Sterile alpha motif
      cd00204
      Location:518643
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:8751097
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      pfam00023
      Location:681710
      Ank; Ankyrin repeat
      pfam00644
      Location:8891092
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam12796
      Location:530622
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:2878
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:528556
      ANK; ANK repeat [structural motif]
    2. XM_006527408.3XP_006527471.1  tankyrase-2 isoform X1

      Conserved Domains (8) summary
      cd09524
      Location:814879
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      smart00454
      Location:820876
      SAM; Sterile alpha motif
      cd00204
      Location:461586
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:8811103
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      pfam00644
      Location:8951098
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam12796
      Location:473565
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:2878
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:471499
      ANK; ANK repeat [structural motif]
    3. XM_011247382.2XP_011245684.1  tankyrase-2 isoform X3

      Conserved Domains (4) summary
      cd00204
      Location:518643
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:530622
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:2878
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:528556
      ANK; ANK repeat [structural motif]
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