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    Pgs1 phosphatidylglycerophosphate synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74451, updated on 3-Apr-2018

    Summary

    Official Symbol
    Pgs1provided by MGI
    Official Full Name
    phosphatidylglycerophosphate synthase 1provided by MGI
    Primary source
    MGI:MGI:1921701
    See related
    Ensembl:ENSMUSG00000017715 Vega:OTTMUSG00000003736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SAF; 2610019F11Rik; 4933424M23Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 69.2), lung adult (RPKM 38.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pgs1 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (117986297..118024011)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (117848171..117885325)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11725 Neighboring gene threonine aldolase 1 Neighboring gene suppressor of cytokine signaling 3 Neighboring gene microRNA 6933 Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene predicted gene, 38514 Neighboring gene cytohesin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    cardiolipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
    Names
    PGP synthase 1
    silencer-associated factor
    NP_598518.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133757.2NP_598518.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_598518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer protein-coding transcript.
      Source sequence(s)
      AK049359
      Consensus CDS
      CCDS25698.1
      UniProtKB/Swiss-Prot
      Q8BHF7
      UniProtKB/TrEMBL
      B9EKS7
      Related
      ENSMUSP00000121973.1, OTTMUSP00000003964, ENSMUST00000132676.7, OTTMUST00000008137
      Conserved Domains (2) summary
      cd09135
      Location:93266
      PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
      cd09137
      Location:346505
      PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases

    RNA

    1. NR_151726.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK046174, AK049359, AK163967, AW045732

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      117986297..118024011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_388543.1 RNA Sequence

    2. XR_388542.1 RNA Sequence

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