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    Pank2 pantothenate kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 74450, updated on 8-Jul-2021

    Summary

    Official Symbol
    Pank2provided by MGI
    Official Full Name
    pantothenate kinase 2provided by MGI
    Primary source
    MGI:MGI:1921700
    See related
    Ensembl:ENSMUSG00000037514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hPanK2; AI642621; 4933409I19Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.4), limb E14.5 (RPKM 11.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pank2 in Genome Data Viewer
    Location:
    2; 2 F1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131103928..131141108)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131262008..131299188)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131088236..131124924)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adaptor-related protein 5 complex, sigma 1 subunit Neighboring gene mitochondrial antiviral signaling protein Neighboring gene microRNA 103-2 Neighboring gene ring finger protein 24 Neighboring gene small nuclear ribonucleoprotein E, pseudogene Neighboring gene predicted gene, 30590

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118448

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pantothenate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pantothenate kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables pantothenate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pantothenate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    NOT located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pantothenate kinase 2, mitochondrial
    Names
    pantothenate kinase 2 (Hallervorden-Spatz syndrome)
    pantothenic acid kinase 2
    NP_001342608.1
    NP_001342610.1
    NP_001342611.1
    NP_001342612.1
    NP_705721.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355679.1NP_001342608.1  pantothenate kinase 2, mitochondrial isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK082821, AL808128
      Related
      ENSMUST00000131779.8
      Conserved Domains (1) summary
      pfam03630
      Location:87344
      Fumble
    2. NM_001355681.1NP_001342610.1  pantothenate kinase 2, mitochondrial isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AL808128
      Conserved Domains (1) summary
      pfam03630
      Location:1271
      Fumble
    3. NM_001355682.1NP_001342611.1  pantothenate kinase 2, mitochondrial isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AL808128
      Conserved Domains (1) summary
      pfam03630
      Location:1271
      Fumble
    4. NM_001355683.1NP_001342612.1  pantothenate kinase 2, mitochondrial isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three alternate coding exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL808128
      Conserved Domains (1) summary
      cl17037
      Location:87250
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. NM_153501.3NP_705721.3  pantothenate kinase 2, mitochondrial isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). It uses a non-AUG translation start site (PMID: 15105273).
      Source sequence(s)
      AL808128
      Consensus CDS
      CCDS16761.1
      Related
      ENSMUSP00000119606.3, ENSMUST00000150843.9
      Conserved Domains (1) summary
      pfam03630
      Location:100448
      Fumble

    RNA

    1. NR_149747.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL808128
      Related
      ENSMUST00000184932.9
    2. NR_149748.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' end and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK016755, AL808128

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131103928..131141108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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