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    Polr3c polymerase (RNA) III (DNA directed) polypeptide C [ Mus musculus (house mouse) ]

    Gene ID: 74414, updated on 9-Sep-2018

    Summary

    Official Symbol
    Polr3cprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Cprovided by MGI
    Primary source
    MGI:MGI:1921664
    See related
    Ensembl:ENSMUSG00000028099 Vega:OTTMUSG00000033832
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPC3; RPC62; 4933407E01Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 19.8), testis adult (RPKM 14.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Polr3c in Genome Data Viewer
    Location:
    3; 3 F2.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (96711518..96727493, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (96515818..96531362, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 35 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 17 Neighboring gene ring finger protein 115 Neighboring gene CD160 antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC3
    Names
    DNA-directed RNA polymerase III subunit C
    RNA polymerase III subunit C3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028925.1NP_083201.1  DNA-directed RNA polymerase III subunit RPC3

      See identical proteins and their annotated locations for NP_083201.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151028
      Consensus CDS
      CCDS51010.1
      UniProtKB/Swiss-Prot
      Q9D483
      UniProtKB/TrEMBL
      B2RX77
      Related
      ENSMUSP00000029741.2, OTTMUSP00000046020, ENSMUST00000029741.8, OTTMUST00000085229
      Conserved Domains (2) summary
      pfam05645
      Location:146344
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:765
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      96711518..96727493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502187.3XP_006502250.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

      See identical proteins and their annotated locations for XP_006502250.1

      UniProtKB/Swiss-Prot
      Q9D483
      UniProtKB/TrEMBL
      B2RX77
      Related
      ENSMUSP00000122435.1, OTTMUSP00000046023, ENSMUST00000154679.7, OTTMUST00000085233
      Conserved Domains (2) summary
      pfam05645
      Location:146344
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:765
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain
    2. XM_006502188.3XP_006502251.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

      Conserved Domains (1) summary
      pfam05645
      Location:62260
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82

    RNA

    1. XR_867239.2 RNA Sequence

    2. XR_375595.2 RNA Sequence

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