Format

Send to:

Choose Destination
    • Showing Current items.

    Cep57 centrosomal protein 57 [ Mus musculus (house mouse) ]

    Gene ID: 74360, updated on 6-Nov-2018

    Summary

    Official Symbol
    Cep57provided by MGI
    Official Full Name
    centrosomal protein 57provided by MGI
    Primary source
    MGI:MGI:1915551
    See related
    Ensembl:ENSMUSG00000031922 Vega:OTTMUSG00000033418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsp57; AI467480; mKIAA0092; 3110002L15Rik; 4921510P06Rik; 4931428M20Rik
    Expression
    Broad expression in testis adult (RPKM 23.6), CNS E11.5 (RPKM 13.8) and 23 other tissues See more
    Orthologs

    Genomic context

    See Cep57 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (13807783..13827561, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (13612232..13631537, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene mastermind like transcriptional coactivator 2 Neighboring gene per-hexamer repeat gene 4 Neighboring gene predicted gene, 39291 Neighboring gene myotubularin related protein 2 Neighboring gene family with sequence similarity 76, member B Neighboring gene peptidylprolyl isomerase B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein import into nucleus, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein import into nucleus, translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatid development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    centrosomal protein of 57 kDa
    Names
    testis-specific protein 57
    translokin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310721.1NP_001297650.1  centrosomal protein of 57 kDa isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK019414, AK028408, AK028458, AK129053, CT010488
      Consensus CDS
      CCDS80955.1
      UniProtKB/Swiss-Prot
      Q8CEE0
      UniProtKB/TrEMBL
      B8JJE7
      Related
      ENSMUSP00000116931.1, OTTMUSP00000045151, ENSMUST00000147115.7, OTTMUST00000083920
      Conserved Domains (2) summary
      pfam06657
      Location:323393
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:68245
      Cep57_CLD; Centrosome localization domain of Cep57
    2. NM_026665.4NP_080941.3  centrosomal protein of 57 kDa isoform 1

      See identical proteins and their annotated locations for NP_080941.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK028458, AK129053, BB846596, BC050785
      Consensus CDS
      CCDS52724.1
      UniProtKB/Swiss-Prot
      Q8CEE0
      Related
      ENSMUSP00000034398.5, OTTMUSP00000045144, ENSMUST00000034398.11, OTTMUST00000083911
      Conserved Domains (2) summary
      pfam06657
      Location:349419
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:68245
      Cep57_CLD; Centrosome localization domain of Cep57

    RNA

    1. NR_037622.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK016484, AK028458, BC030353

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      13807783..13827561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313667.1XP_017169156.1  centrosomal protein of 57 kDa isoform X1

    2. XM_006510650.1XP_006510713.1  centrosomal protein of 57 kDa isoform X3

      Conserved Domains (2) summary
      pfam06657
      Location:174244
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:196
      Cep57_CLD; Centrosome localization domain of Cep57
    3. XM_006510649.1XP_006510712.1  centrosomal protein of 57 kDa isoform X2

      See identical proteins and their annotated locations for XP_006510712.1

      UniProtKB/Swiss-Prot
      Q8CEE0
      Related
      ENSMUSP00000119081.1, OTTMUSP00000045148, ENSMUST00000124883.7, OTTMUST00000083915
      Conserved Domains (2) summary
      pfam06657
      Location:200270
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:196
      Cep57_CLD; Centrosome localization domain of Cep57

    RNA

    1. XR_001779042.1 RNA Sequence

    Support Center