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    Cep57 centrosomal protein 57 [ Mus musculus (house mouse) ]

    Gene ID: 74360, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cep57provided by MGI
    Official Full Name
    centrosomal protein 57provided by MGI
    Primary source
    MGI:MGI:1915551
    See related
    Ensembl:ENSMUSG00000031922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsp; Tsp57; AI467480; mKIAA0092; 3110002L15Rik; 4921510P06Rik; 4931428M20Rik
    Expression
    Broad expression in testis adult (RPKM 23.6), CNS E11.5 (RPKM 13.8) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cep57 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (13717979..13738698, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (13807783..13827407, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (13612232..13631537, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39291 Neighboring gene predicted gene, 53498 Neighboring gene myotubularin related protein 2 Neighboring gene family with sequence similarity 76, member B Neighboring gene peptidylprolyl isomerase B pseudogene Neighboring gene RIKEN cDNA 1700019J19 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    centrosomal protein of 57 kDa
    Names
    testis-specific protein 57
    translokin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310721.1NP_001297650.1  centrosomal protein of 57 kDa isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK019414, AK028408, AK028458, AK129053, CT010488
      Consensus CDS
      CCDS80955.1
      UniProtKB/Swiss-Prot
      Q8CEE0
      UniProtKB/TrEMBL
      B8JJE7
      Related
      ENSMUSP00000116931.2, ENSMUST00000147115.8
      Conserved Domains (2) summary
      pfam06657
      Location:323393
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:68245
      Cep57_CLD; Centrosome localization domain of Cep57
    2. NM_026665.4NP_080941.3  centrosomal protein of 57 kDa isoform 1

      See identical proteins and their annotated locations for NP_080941.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK028458, AK129053, BB846596, BC050785
      Consensus CDS
      CCDS52724.1
      UniProtKB/Swiss-Prot
      Q8CEE0
      Related
      ENSMUSP00000034398.6, ENSMUST00000034398.12
      Conserved Domains (2) summary
      pfam06657
      Location:349419
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:68245
      Cep57_CLD; Centrosome localization domain of Cep57

    RNA

    1. NR_037622.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK016484, AK028458, BC030353

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      13717979..13738698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510649.3XP_006510712.1  centrosomal protein of 57 kDa isoform X2

      See identical proteins and their annotated locations for XP_006510712.1

      UniProtKB/Swiss-Prot
      Q8CEE0
      Conserved Domains (2) summary
      pfam06657
      Location:200271
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:196
      Cep57_CLD; Centrosome localization domain of Cep57
    2. XM_030244681.2XP_030100541.1  centrosomal protein of 57 kDa isoform X2

      Related
      ENSMUSP00000119081.2, ENSMUST00000124883.8
      Conserved Domains (2) summary
      pfam06657
      Location:200271
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:196
      Cep57_CLD; Centrosome localization domain of Cep57
    3. XM_017313667.3XP_017169156.1  centrosomal protein of 57 kDa isoform X1

      Conserved Domains (2) summary
      pfam06657
      Location:296367
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:41218
      Cep57_CLD; Centrosome localization domain of Cep57

    RNA

    1. XR_001779042.3 RNA Sequence

      Related
      ENSMUST00000142494.8
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