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    Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 74340, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ahcyl2provided by MGI
    Official Full Name
    S-adenosylhomocysteine hydrolase-like 2provided by MGI
    Primary source
    MGI:MGI:1921590
    See related
    Ensembl:ENSMUSG00000029772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI227036; mKIAA0828; Adohcyase3; 4631427C17Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 28.3), kidney adult (RPKM 23.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ahcyl2 in Genome Data Viewer
    Location:
    6; 6 A3.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (29768379..29912310)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29718443..29862310)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene tetraspanin 33 Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene striatin interacting protein 2 Neighboring gene phosphoglycerate kinase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0828

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative adenosylhomocysteinase 3
    Names
    S-adenosyl-L-homocysteine hydrolase 3
    S-adenosylhomocysteine hydrolase-like protein 2
    adenosylhomocysteinase 3
    clone MNCb-5555
    long-IRBIT
    NP_001164471.2
    NP_001164472.1
    NP_067389.5
    XP_006505242.2
    XP_006505243.2
    XP_006505244.1
    XP_006505245.1
    XP_006505246.1
    XP_006505248.1
    XP_011239384.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171000.2NP_001164471.2  putative adenosylhomocysteinase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      BC059255, BC079660, BY733512, CA751283
      Consensus CDS
      CCDS57416.1
      UniProtKB/Swiss-Prot
      Q68FL4
      UniProtKB/TrEMBL
      F8WGT1
      Related
      ENSMUSP00000100060.2, ENSMUST00000102995.8
      Conserved Domains (1) summary
      pfam05221
      Location:186611
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    2. NM_001171001.1NP_001164472.1  putative adenosylhomocysteinase 3 isoform 3

      See identical proteins and their annotated locations for NP_001164472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK053527, BC059255, BC079660, CF745122
      Consensus CDS
      CCDS51738.1
      UniProtKB/Swiss-Prot
      Q68FL4
      Related
      ENSMUSP00000110893.3, ENSMUST00000115238.9
      Conserved Domains (2) summary
      PRK05476
      Location:82502
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:82507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    3. NM_001347084.1NP_001334013.1  putative adenosylhomocysteinase 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate exons in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC079216
      Consensus CDS
      CCDS85024.1
      UniProtKB/TrEMBL
      F8WI65
      Conserved Domains (1) summary
      pfam05221
      Location:82507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    4. NM_021414.6NP_067389.5  putative adenosylhomocysteinase 3 isoform 1

      See identical proteins and their annotated locations for NP_067389.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC059255, BC079660, BY733512
      Consensus CDS
      CCDS19966.3
      UniProtKB/Swiss-Prot
      Q68FL4
      Related
      ENSMUSP00000110897.2, ENSMUST00000115242.8
      Conserved Domains (1) summary
      pfam05221
      Location:187612
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      29768379..29912310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241082.2XP_011239384.1  putative adenosylhomocysteinase 3 isoform X3

      Conserved Domains (2) summary
      PRK05476
      Location:224526
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      cl21454
      Location:224529
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_006505182.2XP_006505245.1  putative adenosylhomocysteinase 3 isoform X5

      See identical proteins and their annotated locations for XP_006505245.1

      Conserved Domains (1) summary
      pfam05221
      Location:83508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    3. XM_006505185.2XP_006505248.1  putative adenosylhomocysteinase 3 isoform X7

      Related
      ENSMUSP00000067638.6, ENSMUST00000064872.12
      Conserved Domains (1) summary
      pfam05221
      Location:82507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    4. XM_006505181.3XP_006505244.1  putative adenosylhomocysteinase 3 isoform X4

      Conserved Domains (2) summary
      PRK05476
      Location:100520
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:100525
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    5. XM_006505183.3XP_006505246.1  putative adenosylhomocysteinase 3 isoform X6

      See identical proteins and their annotated locations for XP_006505246.1

      Conserved Domains (2) summary
      PRK05476
      Location:83503
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:83508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    6. XM_006505179.2XP_006505242.2  putative adenosylhomocysteinase 3 isoform X1

      Conserved Domains (2) summary
      PRK05476
      Location:80500
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:80505
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    7. XM_006505180.2XP_006505243.2  putative adenosylhomocysteinase 3 isoform X2

      Related
      ENSMUSP00000135518.1, ENSMUST00000125911.8
      Conserved Domains (2) summary
      PRK05476
      Location:79499
      PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
      pfam05221
      Location:79504
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
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