Format

Send to:

Choose Destination
    • Showing Current items.

    Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 74340, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ahcyl2provided by MGI
    Official Full Name
    S-adenosylhomocysteine hydrolase-like 2provided by MGI
    Primary source
    MGI:MGI:1921590
    See related
    Ensembl:ENSMUSG00000029772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI227036; mKIAA0828; Adohcyase3; 4631427C17Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 28.3), kidney adult (RPKM 23.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ahcyl2 in Genome Data Viewer
    Location:
    6; 6 A3.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29768378..29912309)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29768379..29912310)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29718443..29862310)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 33 Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene striatin interacting protein 2 Neighboring gene predicted gene, 52897 Neighboring gene phosphoglycerate kinase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0828

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative adenosylhomocysteinase 3
    Names
    S-adenosyl-L-homocysteine hydrolase 3
    S-adenosylhomocysteine hydrolase-like protein 2
    adenosylhomocysteinase 3
    clone MNCb-5555
    long-IRBIT
    NP_001164471.2
    NP_001164472.1
    NP_001334013.1
    NP_067389.5
    XP_006505242.2
    XP_006505243.2
    XP_006505244.1
    XP_006505245.1
    XP_006505246.1
    XP_011239384.1
    XP_030111502.1
    XP_030111503.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171000.2NP_001164471.2  putative adenosylhomocysteinase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      BC059255, BC079660, BY733512, CA751283
      Consensus CDS
      CCDS57416.1
      UniProtKB/Swiss-Prot
      Q68FL4
      UniProtKB/TrEMBL
      F8WGT1
      Related
      ENSMUSP00000100060.3, ENSMUST00000102995.9
      Conserved Domains (1) summary
      pfam05221
      Location:186611
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    2. NM_001171001.1NP_001164472.1  putative adenosylhomocysteinase 3 isoform 3

      See identical proteins and their annotated locations for NP_001164472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK053527, BC059255, BC079660, CF745122
      Consensus CDS
      CCDS51738.1
      UniProtKB/Swiss-Prot
      Q68FL4
      Related
      ENSMUSP00000110893.4, ENSMUST00000115238.10
      Conserved Domains (1) summary
      smart00996
      Location:84507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    3. NM_001347084.1NP_001334013.1  putative adenosylhomocysteinase 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate exons in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC079216
      Consensus CDS
      CCDS85024.1
      UniProtKB/TrEMBL
      F8WI65
      Related
      ENSMUSP00000067638.7, ENSMUST00000064872.13
      Conserved Domains (1) summary
      smart00996
      Location:84507
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    4. NM_021414.6NP_067389.5  putative adenosylhomocysteinase 3 isoform 1

      See identical proteins and their annotated locations for NP_067389.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC059255, BC079660, BY733512
      Consensus CDS
      CCDS19966.3
      UniProtKB/Swiss-Prot
      Q68FL4
      Related
      ENSMUSP00000110897.3, ENSMUST00000115242.9
      Conserved Domains (1) summary
      pfam05221
      Location:187612
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29768378..29912309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241082.3XP_011239384.1  putative adenosylhomocysteinase 3 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:226529
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_030255642.1XP_030111502.1  putative adenosylhomocysteinase 3 isoform X7

      Related
      ENSMUSP00000135518.2, ENSMUST00000125911.9
      Conserved Domains (1) summary
      smart00996
      Location:1403
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    3. XM_030255643.2XP_030111503.1  putative adenosylhomocysteinase 3 isoform X7

      Conserved Domains (1) summary
      smart00996
      Location:1403
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    4. XM_006505182.4XP_006505245.1  putative adenosylhomocysteinase 3 isoform X5

      See identical proteins and their annotated locations for XP_006505245.1

      Conserved Domains (1) summary
      smart00996
      Location:85508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    5. XM_006505181.4XP_006505244.1  putative adenosylhomocysteinase 3 isoform X4

      Conserved Domains (1) summary
      smart00996
      Location:102525
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    6. XM_006505183.4XP_006505246.1  putative adenosylhomocysteinase 3 isoform X6

      See identical proteins and their annotated locations for XP_006505246.1

      Conserved Domains (1) summary
      smart00996
      Location:85508
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    7. XM_006505179.2XP_006505242.2  putative adenosylhomocysteinase 3 isoform X1

      Conserved Domains (1) summary
      smart00996
      Location:82505
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    8. XM_006505180.2XP_006505243.2  putative adenosylhomocysteinase 3 isoform X2

      Related
      ENSMUST00000149816.8
      Conserved Domains (1) summary
      smart00996
      Location:81504
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    Support Center