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    Hnrnpr heterogeneous nuclear ribonucleoprotein R [ Mus musculus (house mouse) ]

    Gene ID: 74326, updated on 23-Sep-2018

    Summary

    Official Symbol
    Hnrnprprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Rprovided by MGI
    Primary source
    MGI:MGI:1891692
    See related
    Ensembl:ENSMUSG00000066037 Vega:OTTMUSG00000009867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpr; 2610003J05Rik; 2610528B01Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 21.4), CNS E14 (RPKM 17.4) and 21 other tissues See more
    Orthologs

    Genomic context

    See Hnrnpr in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (136310942..136345981)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (135866891..135896593)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene zinc finger protein 46 Neighboring gene RIKEN cDNA 9130020K20 gene Neighboring gene predicted gene, 31295

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein R

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277121.1NP_001264050.1  heterogeneous nuclear ribonucleoprotein R isoform a

      See identical proteins and their annotated locations for NP_001264050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK152039, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS18805.1
      UniProtKB/TrEMBL
      Q3U8W9, Q8VHM5
      Related
      ENSMUSP00000101476.1, OTTMUSP00000010489, ENSMUST00000105850.7, OTTMUST00000022977
      Conserved Domains (1) summary
      cl25617
      Location:106627
      LSM_int_assoc; LSM-interacting associated unstructured
    2. NM_001277122.1NP_001264051.1  heterogeneous nuclear ribonucleoprotein R isoform b

      See identical proteins and their annotated locations for NP_001264051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK133840, AK138916, AL670673, AL935264, AW060625, BX537311, BY311081
      Consensus CDS
      CCDS71495.1
      UniProtKB/TrEMBL
      F7B5B5, Q3UZI0
      Related
      ENSMUSP00000081239.5, OTTMUSP00000063673, ENSMUST00000084219.11, OTTMUST00000022982
      Conserved Domains (1) summary
      cl25617
      Location:5526
      LSM_int_assoc; LSM-interacting associated unstructured
    3. NM_001277123.1NP_001264052.1  heterogeneous nuclear ribonucleoprotein R isoform b

      See identical proteins and their annotated locations for NP_001264052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK138916, AK145849, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS71495.1
      UniProtKB/TrEMBL
      F7B5B5, Q3UKV5
      Related
      ENSMUSP00000138263.1, OTTMUSP00000063672, ENSMUST00000131671.7, OTTMUST00000022978
      Conserved Domains (1) summary
      cl25617
      Location:5526
      LSM_int_assoc; LSM-interacting associated unstructured
    4. NM_001355182.1NP_001342111.1  heterogeneous nuclear ribonucleoprotein R isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK152039, AL670673, AL935264, AW060625, BB841005, BX537311, BY138716
      Conserved Domains (1) summary
      cl25617
      Location:106627
      LSM_int_assoc; LSM-interacting associated unstructured
    5. NM_028871.2NP_083147.1  heterogeneous nuclear ribonucleoprotein R isoform a

      See identical proteins and their annotated locations for NP_083147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK145849, AK147043, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS18805.1
      UniProtKB/TrEMBL
      Q3UKV5, Q8VHM5
      Related
      ENSMUSP00000138399.1, OTTMUSP00000010441, ENSMUST00000148843.9, OTTMUST00000022882
      Conserved Domains (1) summary
      cl25617
      Location:106627
      LSM_int_assoc; LSM-interacting associated unstructured

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      136310942..136345981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539228.3XP_006539291.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539291.1

      Conserved Domains (3) summary
      cd12494
      Location:242313
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:143230
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_006539222.1XP_006539285.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539285.1

      Conserved Domains (3) summary
      cd12494
      Location:343414
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:106630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:244331
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_006539227.1XP_006539290.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539290.1

      Conserved Domains (3) summary
      cd12494
      Location:242313
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:143230
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_006539221.1XP_006539284.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539284.1

      Conserved Domains (3) summary
      cd12494
      Location:343414
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:106630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:244331
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_006539226.1XP_006539289.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539289.1

      Conserved Domains (3) summary
      cd12494
      Location:242313
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:143230
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_006539224.3XP_006539287.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539287.1

      Conserved Domains (3) summary
      cd12494
      Location:343414
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:106630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:244331
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. XM_006539223.3XP_006539286.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539286.1

      Conserved Domains (3) summary
      cd12494
      Location:343414
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:106630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:244331
      RRM_SF; RNA recognition motif (RRM) superfamily
    8. XM_017320416.1XP_017175905.1  heterogeneous nuclear ribonucleoprotein R isoform X2

      UniProtKB/TrEMBL
      Q8VHM5
      Conserved Domains (1) summary
      cl25617
      Location:106627
      LSM_int_assoc; LSM-interacting associated unstructured
    9. XM_006539225.3XP_006539288.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539288.1

      Conserved Domains (3) summary
      cd12494
      Location:242313
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:143230
      RRM_SF; RNA recognition motif (RRM) superfamily
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