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    Hnrnpr heterogeneous nuclear ribonucleoprotein R [ Mus musculus (house mouse) ]

    Gene ID: 74326, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hnrnprprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Rprovided by MGI
    Primary source
    MGI:MGI:1891692
    See related
    Ensembl:ENSMUSG00000066037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    h; Hnrpr; 2610003J05Rik; 2610528B01Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 21.4), CNS E14 (RPKM 17.4) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hnrnpr in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136038230..136086758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136310942..136345981)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (135866891..135896593)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene zinc finger protein 46 Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277121.1NP_001264050.1  heterogeneous nuclear ribonucleoprotein R isoform a

      See identical proteins and their annotated locations for NP_001264050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK152039, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS18805.1
      UniProtKB/TrEMBL
      Q3U8W9, Q8VHM5
      Related
      ENSMUSP00000101476.2, ENSMUST00000105850.8
      Conserved Domains (2) summary
      TIGR01648
      Location:106627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
    2. NM_001277122.1NP_001264051.1  heterogeneous nuclear ribonucleoprotein R isoform b

      See identical proteins and their annotated locations for NP_001264051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK133840, AK138916, AL670673, AL935264, AW060625, BX537311, BY311081
      Consensus CDS
      CCDS71495.1
      UniProtKB/TrEMBL
      F7B5B5, Q3UZI0
      Related
      ENSMUSP00000081239.6, ENSMUST00000084219.12
      Conserved Domains (1) summary
      TIGR01648
      Location:5526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    3. NM_001277123.1NP_001264052.1  heterogeneous nuclear ribonucleoprotein R isoform b

      See identical proteins and their annotated locations for NP_001264052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK138916, AK145849, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS71495.1
      UniProtKB/TrEMBL
      F7B5B5, Q3UKV5
      Related
      ENSMUSP00000138263.2, ENSMUST00000131671.8
      Conserved Domains (1) summary
      TIGR01648
      Location:5526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    4. NM_001355182.1NP_001342111.1  heterogeneous nuclear ribonucleoprotein R isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK152039, AL670673, AL935264, AW060625, BB841005, BX537311, BY138716
      Consensus CDS
      CCDS18805.1
      Conserved Domains (2) summary
      TIGR01648
      Location:106627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
    5. NM_028871.2NP_083147.1  heterogeneous nuclear ribonucleoprotein R isoform a

      See identical proteins and their annotated locations for NP_083147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2 and 6 encode the same isoform (a).
      Source sequence(s)
      AK138916, AK145849, AK147043, AL670673, AL935264, AW060625, BX537311
      Consensus CDS
      CCDS18805.1
      UniProtKB/TrEMBL
      Q3UKV5, Q8VHM5
      Related
      ENSMUSP00000138399.2, ENSMUST00000148843.10
      Conserved Domains (2) summary
      TIGR01648
      Location:106627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136038230..136086758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539228.5XP_006539291.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539291.1

      Conserved Domains (1) summary
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    2. XM_006539222.3XP_006539285.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539285.1

      Conserved Domains (2) summary
      TIGR01648
      Location:106630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
    3. XM_036164497.1XP_036020390.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      Conserved Domains (1) summary
      TIGR01648
      Location:5526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    4. XM_006539223.5XP_006539286.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539286.1

      Conserved Domains (2) summary
      TIGR01648
      Location:106630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
    5. XM_030253846.2XP_030109706.1  heterogeneous nuclear ribonucleoprotein R isoform X2

      Conserved Domains (2) summary
      TIGR01648
      Location:106627
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
    6. XM_030253848.2XP_030109708.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      Conserved Domains (1) summary
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    7. XM_030253850.2XP_030109710.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      Conserved Domains (1) summary
      TIGR01648
      Location:5526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    8. XM_006539226.3XP_006539289.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539289.1

      Conserved Domains (1) summary
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    9. XM_006539227.2XP_006539290.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539290.1

      Conserved Domains (1) summary
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    10. XM_006539225.5XP_006539288.1  heterogeneous nuclear ribonucleoprotein R isoform X3

      See identical proteins and their annotated locations for XP_006539288.1

      Conserved Domains (1) summary
      TIGR01648
      Location:5529
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    11. XM_030253849.2XP_030109709.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      Conserved Domains (1) summary
      TIGR01648
      Location:5526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    12. XM_036164499.1XP_036020392.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      Conserved Domains (1) summary
      TIGR01648
      Location:5526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    13. XM_006539224.5XP_006539287.1  heterogeneous nuclear ribonucleoprotein R isoform X1

      See identical proteins and their annotated locations for XP_006539287.1

      Conserved Domains (2) summary
      TIGR01648
      Location:106630
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      pfam18360
      Location:37106
      hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
    14. XM_036164498.1XP_036020391.1  heterogeneous nuclear ribonucleoprotein R isoform X4

      Conserved Domains (1) summary
      TIGR01648
      Location:5526
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    RNA

    1. XR_004941997.1 RNA Sequence

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