Format

Send to:

Choose Destination
    • Showing Current items.

    Rnf145 ring finger protein 145 [ Mus musculus (house mouse) ]

    Gene ID: 74315, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf145provided by MGI
    Official Full Name
    ring finger protein 145provided by MGI
    Primary source
    MGI:MGI:1921565
    See related
    Ensembl:ENSMUSG00000019189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TMRF1; 3732413I11Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.4), CNS E11.5 (RPKM 19.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rnf145 in Genome Data Viewer
    Location:
    11; 11 B1.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (44409486..44456347)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (44518793..44565520)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (44332466..44379022)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene adenosine kinase pseudogene Neighboring gene predicted gene, 51891 Neighboring gene RIKEN cDNA 4930597A21 gene Neighboring gene predicted gene, 39815 Neighboring gene early B cell factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RING finger protein 145
    NP_001160025.1
    NP_001350095.1
    NP_083138.2
    XP_006534420.1
    XP_006534421.1
    XP_030102252.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166553.1NP_001160025.1  RING finger protein 145 isoform 2

      See identical proteins and their annotated locations for NP_001160025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK139310, AL603913
      Consensus CDS
      CCDS48775.1
      UniProtKB/TrEMBL
      Q3UTM8, Q8BU61
      Related
      ENSMUSP00000098881.3, ENSMUST00000101327.3
      Conserved Domains (1) summary
      pfam13705
      Location:8265
      TRC8_N; TRC8 N-terminal domain
    2. NM_001363166.1NP_001350095.1  RING finger protein 145 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL603913
      Consensus CDS
      CCDS24565.1
      Conserved Domains (3) summary
      COG5243
      Location:520627
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16684
      Location:533575
      RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
      pfam13705
      Location:8506
      TRC8_N; TRC8 N-terminal domain
    3. NM_028862.4NP_083138.2  RING finger protein 145 isoform 1

      See identical proteins and their annotated locations for NP_083138.2

      Status: VALIDATED

      Source sequence(s)
      AK014408, AK043002, AL603913, BB618481, CK624836
      Consensus CDS
      CCDS24565.1
      UniProtKB/Swiss-Prot
      Q5SWK7
      Related
      ENSMUSP00000019333.4, ENSMUST00000019333.10
      Conserved Domains (3) summary
      COG5243
      Location:520627
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16684
      Location:533575
      RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
      pfam13705
      Location:8506
      TRC8_N; TRC8 N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      44409486..44456347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534358.4XP_006534421.1  RING finger protein 145 isoform X1

      See identical proteins and their annotated locations for XP_006534421.1

      UniProtKB/Swiss-Prot
      Q5SWK7
      Conserved Domains (3) summary
      COG5243
      Location:520627
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16684
      Location:533575
      RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
      pfam13705
      Location:8506
      TRC8_N; TRC8 N-terminal domain
    2. XM_006534357.3XP_006534420.1  RING finger protein 145 isoform X1

      See identical proteins and their annotated locations for XP_006534420.1

      UniProtKB/Swiss-Prot
      Q5SWK7
      Conserved Domains (3) summary
      COG5243
      Location:520627
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16684
      Location:533575
      RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
      pfam13705
      Location:8506
      TRC8_N; TRC8 N-terminal domain
    3. XM_030246392.1XP_030102252.1  RING finger protein 145 isoform X2

      Conserved Domains (3) summary
      COG5243
      Location:408515
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd16684
      Location:421463
      RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
      pfam13705
      Location:1394
      TRC8_N; TRC8 N-terminal domain
    Support Center