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    Mtmr3 myotubularin related protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 74302, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mtmr3provided by MGI
    Official Full Name
    myotubularin related protein 3provided by MGI
    Primary source
    MGI:MGI:1921552
    See related
    Ensembl:ENSMUSG00000034354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZFYVE10; AI255150; AW557713; FYVE-DSP1; mKIAA0371; 1700092A20Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.9), thymus adult (RPKM 14.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mtmr3 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (4480868..4594862, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4380871..4494818, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11958 Neighboring gene HORMA domain containing 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 11961 Neighboring gene activating signal cointegrator 1 complex subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC78036

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 5-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myotubularin-related protein 3
    Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase
    phosphatidylinositol-3-phosphate phosphatase
    NP_083136.2
    XP_006514908.1
    XP_006514909.1
    XP_006514910.1
    XP_006514911.1
    XP_017170296.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028860.2NP_083136.2  myotubularin-related protein 3

      See identical proteins and their annotated locations for NP_083136.2

      Status: VALIDATED

      Source sequence(s)
      AK122261, AK141138, AW046647, CB249296, CB527330, CF532066, CJ048010, CV557784, CX566279
      Consensus CDS
      CCDS48744.1
      UniProtKB/TrEMBL
      B1ATD5, Q80U24
      Related
      ENSMUSP00000105569.3, ENSMUST00000109943.9
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:10761136
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      pfam06602
      Location:127523
      Myotub-related; Myotubularin-like phosphatase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      4480868..4594862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514845.3XP_006514908.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006514908.1

      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11131182
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      pfam06602
      Location:127523
      Myotub-related; Myotubularin-like phosphatase domain
    2. XM_006514846.3XP_006514909.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006514909.1

      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11131182
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      pfam06602
      Location:127523
      Myotub-related; Myotubularin-like phosphatase domain
    3. XM_006514847.3XP_006514910.1  myotubularin-related protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006514910.1

      UniProtKB/Swiss-Prot
      Q8K296
      Related
      ENSMUSP00000122422.1, ENSMUST00000123506.7
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11131173
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      pfam06602
      Location:127523
      Myotub-related; Myotubularin-like phosphatase domain
    4. XM_017314807.1XP_017170296.1  myotubularin-related protein 3 isoform X4

    5. XM_006514848.3XP_006514911.1  myotubularin-related protein 3 isoform X3

      Related
      ENSMUSP00000116315.1, ENSMUST00000128256.1
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:10761145
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      pfam06602
      Location:127523
      Myotub-related; Myotubularin-like phosphatase domain
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