Format

Send to:

Choose Destination
    • Showing Current items.

    Kcmf1 potassium channel modulatory factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74287, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kcmf1provided by MGI
    Official Full Name
    potassium channel modulatory factor 1provided by MGI
    Primary source
    MGI:MGI:1921537
    See related
    Ensembl:ENSMUSG00000055239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pmc; Pmcf; Debt91; 1700094M07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 46.7), ovary adult (RPKM 17.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcmf1 in Genome Data Viewer
    Location:
    6 C1; 6 32.3 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72818097..72876962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72841114..72899979, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (72791108..72849973, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box) Neighboring gene VISTA enhancer mm1474 Neighboring gene predicted gene, 31249 Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene thymosin, beta 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase KCMF1
    Names
    RING-type E3 ubiquitin transferase KCMF1
    clone DEBT-91
    debt-91
    differentially expressed in branching tubulogenesis 91
    potassium channel modulatory factor DEBT-91
    NP_001334160.1
    NP_062689.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347231.1NP_001334160.1  E3 ubiquitin-protein ligase KCMF1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC153613
      Consensus CDS
      CCDS85066.1
      UniProtKB/TrEMBL
      A0A0N4SV15
      Related
      ENSMUSP00000144910.2, ENSMUST00000204598.3
      Conserved Domains (1) summary
      pfam05605
      Location:2685
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    2. NM_019715.2NP_062689.2  E3 ubiquitin-protein ligase KCMF1 isoform 1

      See identical proteins and their annotated locations for NP_062689.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153613, AK142436, CX734813
      Consensus CDS
      CCDS39518.1
      UniProtKB/Swiss-Prot
      Q80UY2
      Related
      ENSMUSP00000064410.9, ENSMUST00000068697.11
      Conserved Domains (3) summary
      cd02338
      Location:755
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam14571
      Location:280328
      Di19_C; Stress-induced protein Di19, C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72818097..72876962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center