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    Usp20 ubiquitin specific peptidase 20 [ Mus musculus (house mouse) ]

    Gene ID: 74270, updated on 18-Sep-2018

    Summary

    Official Symbol
    Usp20provided by MGI
    Official Full Name
    ubiquitin specific peptidase 20provided by MGI
    Primary source
    MGI:MGI:1921520
    See related
    Ensembl:ENSMUSG00000026854 Vega:OTTMUSG00000011873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vdu2; AI467231; 1700055M05Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 28.5), genital fat pad adult (RPKM 18.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Usp20 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (30982279..31022655)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (30837799..30878175)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene torsin family 1, member B Neighboring gene torsin family 1, member A (torsin A) Neighboring gene cDNA sequence BC005624 Neighboring gene predicted gene, 39786 Neighboring gene formin binding protein 1 Neighboring gene RIKEN cDNA D330023K18 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 20
    Names
    VHL-interacting deubiquitinating enzyme 2
    deubiquitinating enzyme 20
    ubiquitin specific protease 20
    ubiquitin thioesterase 20
    ubiquitin thiolesterase 20
    ubiquitin-specific-processing protease 20
    NP_083122.1
    XP_017174785.1
    XP_017174786.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028846.5NP_083122.1  ubiquitin carboxyl-terminal hydrolase 20

      See identical proteins and their annotated locations for NP_083122.1

      Status: VALIDATED

      Source sequence(s)
      AK047242, AK054279, AK173083, BY251374
      Consensus CDS
      CCDS15893.1
      UniProtKB/Swiss-Prot
      Q8C6M1
      Related
      ENSMUSP00000099913.4, OTTMUSP00000012691, ENSMUST00000102849.10, OTTMUST00000027968
      Conserved Domains (6) summary
      smart00695
      Location:812896
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:445685
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:144292
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:144684
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      pfam12316
      Location:318435
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      30982279..31022655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319296.1XP_017174785.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

    2. XM_017319297.1XP_017174786.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

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