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    Aven apoptosis, caspase activation inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 74268, updated on 27-Nov-2024

    Summary

    Official Symbol
    Avenprovided by MGI
    Official Full Name
    apoptosis, caspase activation inhibitorprovided by MGI
    Primary source
    MGI:MGI:1921518
    See related
    Ensembl:ENSMUSG00000003604 AllianceGenome:MGI:1921518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mAven-L; mAven-S; 1700013A01Rik; 1700056A21Rik
    Summary
    Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of apoptotic process. Predicted to be located in membrane. Is expressed in several structures, including heart; liver; metanephros; spleen; and testis. Orthologous to human AVEN (apoptosis and caspase activation inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 40.7), liver E14 (RPKM 4.4) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Aven in Genome Data Viewer
    Location:
    2 E3; 2 57.04 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112323231..112461598)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112492883..112631253)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:112219168-112219469 Neighboring gene STARR-positive B cell enhancer ABC_E5959 Neighboring gene katanin p80 subunit B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E3389 Neighboring gene STARR-positive B cell enhancer ABC_E11150 Neighboring gene STARR-positive B cell enhancer ABC_E4487 Neighboring gene STARR-seq mESC enhancer starr_05388 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene predicted gene, 22676 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112443695-112443995 Neighboring gene STARR-seq mESC enhancer starr_05389 Neighboring gene STARR-seq mESC enhancer starr_05390 Neighboring gene ryanodine receptor 3 Neighboring gene STARR-seq mESC enhancer starr_05392 Neighboring gene STARR-seq mESC enhancer starr_05393 Neighboring gene STARR-seq mESC enhancer starr_05394 Neighboring gene STARR-seq mESC enhancer starr_05395 Neighboring gene predicted gene, 26505 Neighboring gene transmembrane and coiled-coil domains 5B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124011

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165935.1NP_001159407.1  cell death regulator Aven isoform 2

      See identical proteins and their annotated locations for NP_001159407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BE651622, BE995326, DV646415
      Consensus CDS
      CCDS50660.1
      UniProtKB/TrEMBL
      A2AGL5
      Related
      ENSMUSP00000097184.4, ENSMUST00000099588.4
    2. NM_001355630.1NP_001342559.1  cell death regulator Aven isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL691423
    3. NM_001355631.1NP_001342560.1  cell death regulator Aven isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK005934, AL691423
    4. NM_028844.4NP_083120.2  cell death regulator Aven isoform 1

      See identical proteins and their annotated locations for NP_083120.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL691423, AL731840
      Consensus CDS
      CCDS16557.1
      UniProtKB/Swiss-Prot
      A2AGL4, Q9D9K3
      UniProtKB/TrEMBL
      Q496R6
      Related
      ENSMUSP00000003705.6, ENSMUST00000003705.12

    RNA

    1. NR_149741.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL691423

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      112323231..112461598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001783190.3 RNA Sequence