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    Aven apoptosis, caspase activation inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 74268, updated on 31-Jan-2019

    Summary

    Official Symbol
    Avenprovided by MGI
    Official Full Name
    apoptosis, caspase activation inhibitorprovided by MGI
    Primary source
    MGI:MGI:1921518
    See related
    Ensembl:ENSMUSG00000003604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mAven-L; mAven-S; 1700013A01Rik; 1700056A21Rik
    Expression
    Biased expression in testis adult (RPKM 40.7), liver E14 (RPKM 4.4) and 13 other tissues See more
    Orthologs

    Genomic context

    See Aven in Genome Data Viewer
    Location:
    2; 2 E3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (112492885..112631253)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (112333121..112471410)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene katanin p80 subunit B like 1 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene ryanodine receptor 3 Neighboring gene transmembrane and coiled-coil domains 5B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124011

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165935.1NP_001159407.1  cell death regulator Aven isoform 2

      See identical proteins and their annotated locations for NP_001159407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BE651622, BE995326, DV646415
      Consensus CDS
      CCDS50660.1
      UniProtKB/TrEMBL
      A2AGL5
      Related
      ENSMUSP00000097184.3, ENSMUST00000099588.3
    2. NM_001355630.1NP_001342559.1  cell death regulator Aven isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL691423
    3. NM_001355631.1NP_001342560.1  cell death regulator Aven isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK005934, AL691423
    4. NM_028844.3NP_083120.2  cell death regulator Aven isoform 1

      See identical proteins and their annotated locations for NP_083120.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK006808, BE651622, BE995326, BX528932
      Consensus CDS
      CCDS16557.1
      UniProtKB/Swiss-Prot
      Q9D9K3
      Related
      ENSMUSP00000003705.5, ENSMUST00000003705.11

    RNA

    1. NR_149741.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL691423

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      112492885..112631253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500296.2XP_006500359.1  cell death regulator Aven isoform X1

    RNA

    1. XR_001783190.1 RNA Sequence

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