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    Gpn1 GPN-loop GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74254, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gpn1provided by MGI
    Official Full Name
    GPN-loop GTPase 1provided by MGI
    Primary source
    MGI:MGI:1921504
    See related
    Ensembl:ENSMUSG00000064037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xab1; MBDIN; NTPBP; AI449615; 2410004J02Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.8), CNS E14 (RPKM 10.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gpn1 in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (31494752..31511631)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31797134..31814000)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 512 Neighboring gene RIKEN cDNA 4930548H24 gene Neighboring gene suppressor of Ty 7-like Neighboring gene solute carrier family 4 (anion exchanger), member 1, adaptor protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GPN-loop GTPase 1
    Names
    MBD2-interacting protein
    XPA binding protein 1
    methyl-CpG binding domain protein 2 interacting protein
    NP_598517.1
    XP_006504224.1
    XP_006504225.1
    XP_011239076.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133756.5NP_598517.1  GPN-loop GTPase 1

      See identical proteins and their annotated locations for NP_598517.1

      Status: VALIDATED

      Source sequence(s)
      AC113276, AK146686
      Consensus CDS
      CCDS19185.1
      UniProtKB/Swiss-Prot
      Q8VCE2
      UniProtKB/TrEMBL
      Q4VAB2
      Related
      ENSMUSP00000076217.6, ENSMUST00000076949.12
      Conserved Domains (2) summary
      COG1100
      Location:20229
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:24261
      ATP_bind_1; Conserved hypothetical ATP binding protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      31494752..31511631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504162.2XP_006504225.1  GPN-loop GTPase 1 isoform X2

      See identical proteins and their annotated locations for XP_006504225.1

      Conserved Domains (2) summary
      COG1100
      Location:1150
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:1182
      ATP_bind_1; Conserved hypothetical ATP binding protein
    2. XM_006504161.3XP_006504224.1  GPN-loop GTPase 1 isoform X1

      Conserved Domains (2) summary
      COG1100
      Location:1193
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:2225
      ATP_bind_1; Conserved hypothetical ATP binding protein
    3. XM_011240774.2XP_011239076.1  GPN-loop GTPase 1 isoform X2

      See identical proteins and their annotated locations for XP_011239076.1

      Conserved Domains (2) summary
      COG1100
      Location:1150
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:1182
      ATP_bind_1; Conserved hypothetical ATP binding protein
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