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    Acsl3 acyl-CoA synthetase long-chain family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 74205, updated on 31-Jan-2019

    Summary

    Official Symbol
    Acsl3provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 3provided by MGI
    Primary source
    MGI:MGI:1921455
    See related
    Ensembl:ENSMUSG00000032883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acs3; Facl3; C85929; Pro2194; 2610510B12Rik
    Expression
    Broad expression in cortex adult (RPKM 21.5), frontal lobe adult (RPKM 18.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See Acsl3 in Genome Data Viewer
    Location:
    1 C4; 1 40.84 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (78657825..78707743)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (78654400..78704318)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene uncharacterized LOC108167629 Neighboring gene UTP14B small subunit processome component Neighboring gene predicted gene, 38631 Neighboring gene predicted gene, 33693 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    decanoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
     
    very-low-density lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 3
    Names
    LACS 3
    fatty acid Coenzyme A ligase, long chain 3
    long-chain acyl-CoA synthetase 3
    NP_001028778.2
    NP_001129694.1
    NP_083093.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033606.2NP_001028778.2  long-chain-fatty-acid--CoA ligase 3 isoform a

      See identical proteins and their annotated locations for NP_001028778.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK012088, AK046000, AK161708, CK379747
      Consensus CDS
      CCDS15087.1
      UniProtKB/Swiss-Prot
      Q9CZW4
      Related
      ENSMUSP00000121695.1, ENSMUST00000142704.7
      Conserved Domains (2) summary
      cd05927
      Location:130717
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:30717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein
    2. NM_001136222.1NP_001129694.1  long-chain-fatty-acid--CoA ligase 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK046000, AK160839, AK161708, CK379747
      Consensus CDS
      CCDS48295.1
      UniProtKB/Swiss-Prot
      Q9CZW4
      UniProtKB/TrEMBL
      E9PUC2
      Related
      ENSMUSP00000117952.1, ENSMUST00000134566.7
      Conserved Domains (1) summary
      cd05927
      Location:2565
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. NM_028817.3NP_083093.2  long-chain-fatty-acid--CoA ligase 3 isoform a

      See identical proteins and their annotated locations for NP_083093.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK046000, AK161708, CK379747
      Consensus CDS
      CCDS15087.1
      UniProtKB/Swiss-Prot
      Q9CZW4
      Related
      ENSMUSP00000045291.8, ENSMUST00000035779.14
      Conserved Domains (2) summary
      cd05927
      Location:130717
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:30717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      78657825..78707743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_039198.1 Reference GRCm38.p4 129S6/SvEvTac

      Range
      5454..29688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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