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    Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74203, updated on 8-Aug-2021

    Summary

    Official Symbol
    Eif4enif1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E nuclear import factor 1provided by MGI
    Primary source
    MGI:MGI:1921453
    See related
    Ensembl:ENSMUSG00000020454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cla; Clast4; AA410001; AU021239; D11Ertd166; D11Ertd166e; 2610509L04Rik; A930019J01Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.2), CNS E11.5 (RPKM 15.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eif4enif1 in Genome Data Viewer
    Location:
    11 A1; 11 2.24 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3152344..3194588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3202343..3244588)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (3102356..3144591)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene elongation factor 2 pseudogene Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene predicted gene, 51877 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E transporter
    Names
    4E-T
    CD40 ligand-activated specific transcript 4
    eIF4E transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166547.1NP_001160019.1  eukaryotic translation initiation factor 4E transporter isoform a

      See identical proteins and their annotated locations for NP_001160019.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK165678, BC033410
      Consensus CDS
      CCDS24354.1
      UniProtKB/Swiss-Prot
      Q9EST3
      Related
      ENSMUSP00000136768.2, ENSMUST00000179770.8
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    2. NM_001166548.1NP_001160020.1  eukaryotic translation initiation factor 4E transporter isoform b

      See identical proteins and their annotated locations for NP_001160020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK041598, BC033410, CJ072393
      Consensus CDS
      CCDS48739.1
      UniProtKB/Swiss-Prot
      Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000020734.5, ENSMUST00000020734.11
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    3. NM_001166549.1NP_001160021.1  eukaryotic translation initiation factor 4E transporter isoform b

      See identical proteins and their annotated locations for NP_001160021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC033410, BY068596
      Consensus CDS
      CCDS48739.1
      UniProtKB/Swiss-Prot
      Q9EST3
      Related
      ENSMUSP00000105675.2, ENSMUST00000110048.8
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    4. NM_023743.2NP_076232.2  eukaryotic translation initiation factor 4E transporter isoform a

      See identical proteins and their annotated locations for NP_076232.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AL671968, BC033410
      Consensus CDS
      CCDS24354.1
      UniProtKB/Swiss-Prot
      Q9EST3
      Related
      ENSMUSP00000105676.2, ENSMUST00000110049.8
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3152344..3194588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514842.5XP_006514905.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514905.1

      UniProtKB/Swiss-Prot
      Q9EST3
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    2. XM_006514844.4XP_006514907.1  eukaryotic translation initiation factor 4E transporter isoform X2

      See identical proteins and their annotated locations for XP_006514907.1

      UniProtKB/Swiss-Prot
      Q9EST3
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    3. XM_006514841.4XP_006514904.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514904.1

      UniProtKB/Swiss-Prot
      Q9EST3
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    4. XM_017314806.3XP_017170295.1  eukaryotic translation initiation factor 4E transporter isoform X2

      UniProtKB/Swiss-Prot
      Q9EST3
      Conserved Domains (2) summary
      pfam03154
      Location:683910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    5. XM_006514843.5XP_006514906.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514906.1

      UniProtKB/Swiss-Prot
      Q9EST3
      Conserved Domains (2) summary
      pfam03154
      Location:707934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
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