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    Dtx2 deltex 2, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 74198, updated on 2-Oct-2018

    Summary

    Official Symbol
    Dtx2provided by MGI
    Official Full Name
    deltex 2, E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:1921448
    See related
    Ensembl:ENSMUSG00000004947 Vega:OTTMUSG00000025375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Deltex2; AA408415; AU022494; 2610524D08Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 19.1), thymus adult (RPKM 16.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dtx2 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135994800..136032881)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136470747..136508734)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene scavenger receptor cysteine rich family, 4 domains Neighboring gene zona pellucida glycoprotein 3 Neighboring gene uroplakin 3B Neighboring gene uroplakin 3B-like Neighboring gene predicted gene, 40347

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase DTX2
    Names
    RING-type E3 ubiquitin transferase DTX2
    deltex 2 homolog
    mDTX2
    protein deltex-2
    NP_001243025.1
    NP_001243026.1
    NP_001243027.1
    NP_076231.1
    XP_006504569.1
    XP_006504570.1
    XP_006504571.1
    XP_006504573.1
    XP_017176609.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256096.1NP_001243025.1  probable E3 ubiquitin-protein ligase DTX2 isoform 1

      See identical proteins and their annotated locations for NP_001243025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK012137, BB428288, CF913708
      Consensus CDS
      CCDS57389.1
      UniProtKB/Swiss-Prot
      Q8R3P2
      Related
      ENSMUSP00000106772.2, OTTMUSP00000030793, ENSMUST00000111142.8, OTTMUST00000062461
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:478610
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:408471
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001256097.1NP_001243026.1  probable E3 ubiquitin-protein ligase DTX2 isoform 3

      See identical proteins and their annotated locations for NP_001243026.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
      Source sequence(s)
      AK044105, BB428288, CF913708
      Consensus CDS
      CCDS57390.1
      UniProtKB/Swiss-Prot
      Q8R3P2
      Related
      ENSMUSP00000106774.1, OTTMUSP00000030795, ENSMUST00000111144.7, OTTMUST00000062463
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:432564
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:362425
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_001256098.1NP_001243027.1  probable E3 ubiquitin-protein ligase DTX2 isoform 3

      See identical proteins and their annotated locations for NP_001243027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
      Source sequence(s)
      AK054443, BB428288, CF913708
      Consensus CDS
      CCDS57390.1
      UniProtKB/Swiss-Prot
      Q8R3P2
      Related
      ENSMUSP00000106775.3, OTTMUSP00000030794, ENSMUST00000111145.9, OTTMUST00000062462
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:432564
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:362425
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    4. NM_023742.2NP_076231.1  probable E3 ubiquitin-protein ligase DTX2 isoform 2

      See identical proteins and their annotated locations for NP_076231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
      Source sequence(s)
      AB015423, BB443180, CF913708
      Consensus CDS
      CCDS39322.1
      UniProtKB/Swiss-Prot
      Q8R3P2
      UniProtKB/TrEMBL
      A0A0R4IZY1
      Related
      ENSMUSP00000005072.3, OTTMUSP00000030797, ENSMUST00000005072.9, OTTMUST00000062465
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:477609
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:407470
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      135994800..136032881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504508.1XP_006504571.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      See identical proteins and their annotated locations for XP_006504571.1

      UniProtKB/Swiss-Prot
      Q8R3P2
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:478610
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:408471
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. XM_006504507.2XP_006504570.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      See identical proteins and their annotated locations for XP_006504570.1

      UniProtKB/Swiss-Prot
      Q8R3P2
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:478610
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:408471
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. XM_006504506.3XP_006504569.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      See identical proteins and their annotated locations for XP_006504569.1

      UniProtKB/Swiss-Prot
      Q8R3P2
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:478610
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:408471
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    4. XM_017321120.1XP_017176609.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R3P2
      Conserved Domains (3) summary
      smart00678
      Location:21105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:432564
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:362425
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    5. XM_006504510.3XP_006504573.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

      Conserved Domains (2) summary
      cd09633
      Location:184316
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:114177
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
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