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    Katnb1 katanin p80 (WD40-containing) subunit B 1 [ Mus musculus (house mouse) ]

    Gene ID: 74187, updated on 17-Aug-2021

    Summary

    Official Symbol
    Katnb1provided by MGI
    Official Full Name
    katanin p80 (WD40-containing) subunit B 1provided by MGI
    Primary source
    MGI:MGI:1921437
    See related
    Ensembl:ENSMUSG00000031787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KA; KAT; 2410003J24Rik
    Expression
    Broad expression in testis adult (RPKM 79.1), whole brain E14.5 (RPKM 14.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Katnb1 in Genome Data Viewer
    Location:
    8; 8 C5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95807804..95826502)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95081175..95099874)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (97605101..97623774)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene kinesin family member C3 Neighboring gene predicted gene, 31224 Neighboring gene predicted gene, 31036

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule severing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    part_of katanin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of katanin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    katanin p80 WD40 repeat-containing subunit B1
    Names
    katanin p80 subunit B1
    p80 katanin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028805.2NP_083081.2  katanin p80 WD40 repeat-containing subunit B1

      See identical proteins and their annotated locations for NP_083081.2

      Status: VALIDATED

      Source sequence(s)
      AK031630, AK034103, AK136322, BB842538
      Consensus CDS
      CCDS22555.1
      UniProtKB/Swiss-Prot
      Q8BG40
      Related
      ENSMUSP00000034239.8, ENSMUST00000034239.9
      Conserved Domains (4) summary
      cd00200
      Location:7257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67103
      7WD40; WD40 repeat [structural motif]
      pfam02063
      Location:367465
      MARCKS; MARCKS family
      pfam13925
      Location:500651
      Katanin_con80; con80 domain of Katanin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95807804..95826502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531411.5XP_006531474.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      See identical proteins and their annotated locations for XP_006531474.1

      UniProtKB/Swiss-Prot
      Q8BG40
      Conserved Domains (4) summary
      cd00200
      Location:7257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67103
      7WD40; WD40 repeat [structural motif]
      pfam02063
      Location:367465
      MARCKS; MARCKS family
      pfam13925
      Location:500651
      Katanin_con80; con80 domain of Katanin
    2. XM_006531412.1XP_006531475.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      See identical proteins and their annotated locations for XP_006531475.1

      UniProtKB/Swiss-Prot
      Q8BG40
      Conserved Domains (4) summary
      cd00200
      Location:7257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67103
      7WD40; WD40 repeat [structural motif]
      pfam02063
      Location:367465
      MARCKS; MARCKS family
      pfam13925
      Location:500651
      Katanin_con80; con80 domain of Katanin
    3. XM_006531410.4XP_006531473.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      See identical proteins and their annotated locations for XP_006531473.1

      UniProtKB/Swiss-Prot
      Q8BG40
      Conserved Domains (4) summary
      cd00200
      Location:7257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67103
      7WD40; WD40 repeat [structural motif]
      pfam02063
      Location:367465
      MARCKS; MARCKS family
      pfam13925
      Location:500651
      Katanin_con80; con80 domain of Katanin

    RNA

    1. XR_001778484.2 RNA Sequence

    2. XR_387781.4 RNA Sequence

    3. XR_001778483.2 RNA Sequence

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