Format

Send to:

Choose Destination
    • Showing Current items.

    Gpcpd1 glycerophosphocholine phosphodiesterase 1 [ Mus musculus (house mouse) ]

    Gene ID: 74182, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gpcpd1provided by MGI
    Official Full Name
    glycerophosphocholine phosphodiesterase 1provided by MGI
    Primary source
    MGI:MGI:104898
    See related
    Ensembl:ENSMUSG00000027346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gde5; Prei4; AU015213; mKIAA1434; 2310004G06Rik; 2310032D16Rik
    Expression
    Broad expression in cortex adult (RPKM 15.8), frontal lobe adult (RPKM 14.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See Gpcpd1 in Genome Data Viewer
    Location:
    2 F2; 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (132529082..132578258, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (132354819..132403984, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700026D11 gene Neighboring gene predicted gene 14095 Neighboring gene expressed sequence AU019990 Neighboring gene ribosomal protein L23A, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    glycerophosphocholine phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerophosphocholine phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycerophosphocholine phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    starch binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glycerophosphocholine phosphodiesterase GPCPD1
    Names
    glycerophosphocholine phosphodiesterase GDE1 homolog
    glycerophosphodiester phosphodiesterase 5
    preimplantation protein 4
    putative glycerophosphocholine phosphodiesterase GPCPD1
    putative glycerophosphodiester phosphodiesterase 5
    NP_001036137.1
    NP_001277979.1
    NP_001277980.1
    NP_001277981.1
    NP_081372.1
    NP_083078.3
    XP_006500337.1
    XP_006500338.1
    XP_006500339.1
    XP_006500340.1
    XP_006500342.1
    XP_006500343.1
    XP_011238111.1
    XP_011238112.1
    XP_017174782.1
    XP_017174783.1
    XP_017174784.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042672.1NP_001036137.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 8. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 4.
      Source sequence(s)
      AK031658, AK141374, AL807386
      Conserved Domains (3) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322613
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
      pfam03009
      Location:326613
      GDPD; Glycerophosphoryl diester phosphodiesterase family
    2. NM_001291050.1NP_001277979.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

      See identical proteins and their annotated locations for NP_001277979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
      Source sequence(s)
      AK031658, AW125284
      Consensus CDS
      CCDS71151.1
      UniProtKB/Swiss-Prot
      Q8C0L9
      Conserved Domains (1) summary
      cd08607
      Location:138430
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    3. NM_001291051.1NP_001277980.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

      See identical proteins and their annotated locations for NP_001277980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
      Source sequence(s)
      AK031658, AK163419, AW125284
      Consensus CDS
      CCDS71151.1
      UniProtKB/Swiss-Prot
      Q8C0L9
      Related
      ENSMUSP00000105763.1, ENSMUST00000110136.7
      Conserved Domains (1) summary
      cd08607
      Location:138430
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    4. NM_001291052.1NP_001277981.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

      See identical proteins and their annotated locations for NP_001277981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
      Source sequence(s)
      AK031658, AL807386, AW125284
      Consensus CDS
      CCDS71151.1
      UniProtKB/Swiss-Prot
      Q8C0L9
      Conserved Domains (1) summary
      cd08607
      Location:138430
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    5. NM_001355648.1NP_001342577.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
      Source sequence(s)
      AL807386
      Conserved Domains (1) summary
      cd08607
      Location:138430
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    6. NM_001355649.1NP_001342578.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) represents the longest transcript and encodes the longest isoform (4). Variants 8 and 9 both encode isoform 4.
      Source sequence(s)
      AL807386
      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322621
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    7. NM_001355650.1NP_001342579.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 8. Variants 8 and 9 both encode the same isoform (4).
      Source sequence(s)
      AL807386
      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322621
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    8. NM_001355651.1NP_001342580.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an alternate in-frame exon compared to variant 8. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AL807386
      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322614
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    9. NM_001355652.1NP_001342581.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 8. The resulting isoform (5) is shorter at the N-terminus compared to isoform 4.
      Source sequence(s)
      AL807386
      Conserved Domains (1) summary
      cd08607
      Location:138437
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    10. NM_027096.2NP_081372.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform 1

      See identical proteins and their annotated locations for NP_081372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and lacks an in-frame exon compared to variant 8. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 4. Variants 1, 5, 6, 7, and 12 all encode the same isoform (1).
      Source sequence(s)
      AK031658, AK050318, AW125284, BC033408
      Consensus CDS
      CCDS71151.1
      UniProtKB/Swiss-Prot
      Q8C0L9
      Conserved Domains (1) summary
      cd08607
      Location:138430
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    11. NM_028802.3NP_083078.3  glycerophosphocholine phosphodiesterase GPCPD1 isoform 2

      See identical proteins and their annotated locations for NP_083078.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 8. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AK030645, AK031658, AK050318, AW125284
      Consensus CDS
      CCDS38246.1
      UniProtKB/Swiss-Prot
      Q8C0L9
      Related
      ENSMUSP00000062221.5, ENSMUST00000060955.11
      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322614
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      132529082..132578258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500274.3XP_006500337.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322621
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    2. XM_006500275.3XP_006500338.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X1

      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322621
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    3. XM_011239809.2XP_011238111.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X2

      UniProtKB/Swiss-Prot
      Q8C0L9
      Related
      ENSMUSP00000105769.1, ENSMUST00000110142.7
      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cd08607
      Location:322614
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    4. XM_017319294.1XP_017174783.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X3

      Conserved Domains (1) summary
      cd08607
      Location:138437
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    5. XM_006500280.3XP_006500343.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X3

      See identical proteins and their annotated locations for XP_006500343.1

      Conserved Domains (1) summary
      cd08607
      Location:138437
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    6. XM_006500276.3XP_006500339.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X3

      See identical proteins and their annotated locations for XP_006500339.1

      Conserved Domains (1) summary
      cd08607
      Location:138437
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    7. XM_006500279.3XP_006500342.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X3

      See identical proteins and their annotated locations for XP_006500342.1

      Conserved Domains (1) summary
      cd08607
      Location:138437
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    8. XM_006500277.3XP_006500340.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X3

      See identical proteins and their annotated locations for XP_006500340.1

      Conserved Domains (1) summary
      cd08607
      Location:138437
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    9. XM_017319293.1XP_017174782.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X3

      Conserved Domains (1) summary
      cd08607
      Location:138437
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    10. XM_017319295.1XP_017174784.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X4

      UniProtKB/Swiss-Prot
      Q8C0L9
      Conserved Domains (1) summary
      cd08607
      Location:138430
      GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    11. XM_011239810.2XP_011238112.1  glycerophosphocholine phosphodiesterase GPCPD1 isoform X5

      Conserved Domains (2) summary
      cd05814
      Location:4127
      CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
      cl14615
      Location:322400
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001042671.1: Suppressed sequence

      Description
      NM_001042671.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Support Center