Format

Send to:

Choose Destination
    • Showing Current items.

    Stk40 serine/threonine kinase 40 [ Mus musculus (house mouse) ]

    Gene ID: 74178, updated on 27-Jan-2018

    Summary

    Official Symbol
    Stk40provided by MGI
    Official Full Name
    serine/threonine kinase 40provided by MGI
    Primary source
    MGI:MGI:1921428
    See related
    Ensembl:ENSMUSG00000042608 Vega:OTTMUSG00000009292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI428792; 2310004N11Rik
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 18.0), lung adult (RPKM 15.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Stk40 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (126103860..126141029)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (125781201..125818273)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene U7 snRNP-specific Sm-like protein LSM10 Neighboring gene eva-1 homolog B (C. elegans) Neighboring gene SH3 domain containing 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 40
    Names
    ortholog of Ser/Thr-like protein kinase Lyk4
    serine/threonine-protein kinase lyk4
    NP_001139299.1
    NP_083076.3
    XP_006503504.1
    XP_006503505.1
    XP_017175903.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145827.1NP_001139299.1  serine/threonine-protein kinase 40 isoform a

      See identical proteins and their annotated locations for NP_001139299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL731780, AY336057, BQ030783, CJ170090, DV660319
      Consensus CDS
      CCDS51299.1
      UniProtKB/Swiss-Prot
      Q7TNL3
      Related
      ENSMUSP00000111990.2, ENSMUST00000116286.8
      Conserved Domains (2) summary
      smart00220
      Location:66340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13974
      Location:52344
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
    2. NM_028800.3NP_083076.3  serine/threonine-protein kinase 40 isoform b

      See identical proteins and their annotated locations for NP_083076.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AY336057, BQ030783, CJ170090, DV660319
      Consensus CDS
      CCDS51300.1
      UniProtKB/Swiss-Prot
      Q7TNL3
      Related
      ENSMUSP00000092354.4, OTTMUSP00000009659, ENSMUST00000094761.10, OTTMUST00000021082
      Conserved Domains (2) summary
      smart00220
      Location:52326
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13974
      Location:38330
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      126103860..126141029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503441.3XP_006503504.1  serine/threonine-protein kinase 40 isoform X1

      See identical proteins and their annotated locations for XP_006503504.1

      UniProtKB/Swiss-Prot
      Q7TNL3
      Conserved Domains (2) summary
      smart00220
      Location:66340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13974
      Location:52344
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
    2. XM_017320414.1XP_017175903.1  serine/threonine-protein kinase 40 isoform X2

      UniProtKB/Swiss-Prot
      Q7TNL3
      Conserved Domains (2) summary
      smart00220
      Location:52326
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13974
      Location:38330
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
    3. XM_006503442.1XP_006503505.1  serine/threonine-protein kinase 40 isoform X2

      See identical proteins and their annotated locations for XP_006503505.1

      UniProtKB/Swiss-Prot
      Q7TNL3
      Conserved Domains (2) summary
      smart00220
      Location:52326
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13974
      Location:38330
      STKc_SHIK; Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase
    Support Center