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    VDAC2 voltage dependent anion channel 2 [ Homo sapiens (human) ]

    Gene ID: 7417, updated on 9-Jun-2024

    Summary

    Official Symbol
    VDAC2provided by HGNC
    Official Full Name
    voltage dependent anion channel 2provided by HGNC
    Primary source
    HGNC:HGNC:12672
    See related
    Ensembl:ENSG00000165637 MIM:193245; AllianceGenome:HGNC:12672
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POR
    Summary
    This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in heart (RPKM 81.3), esophagus (RPKM 66.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See VDAC2 in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75210170..75231448)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (76083655..76104942)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76969928..76991206)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 8 Neighboring gene uncharacterized LOC124902460 Neighboring gene ribosomal protein S26 pseudogene 42 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76898750-76898917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76901445-76901944 Neighboring gene MPRA-validated peak1024 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76966815-76967564 Neighboring gene Sharpr-MPRA regulatory region 10124 Neighboring gene Sharpr-MPRA regulatory region 7934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76982209-76982964 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76983719-76984474 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76985985-76986738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2513 Neighboring gene Sharpr-MPRA regulatory region 13796 Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene VISTA enhancer hs1437 Neighboring gene ribosomal protein L39 pseudogene 25

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with voltage-dependent anion channel 2 (VDAC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with voltage-dependent anion channel 2 (VDAC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of voltage-dependent anion channel 2 (VDAC2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ceramide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated monoatomic anion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    voltage-dependent anion-selective channel protein 2
    Names
    epididymis secretory sperm binding protein
    outer mitochondrial membrane protein porin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184783.3NP_001171712.1  voltage-dependent anion-selective channel protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL390034, AL392111
      Consensus CDS
      CCDS53544.1
      UniProtKB/TrEMBL
      A0A0A0MR02
      Related
      ENSP00000361635.1, ENST00000313132.8
      Conserved Domains (1) summary
      cd07306
      Location:30308
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    2. NM_001184823.2NP_001171752.1  voltage-dependent anion-selective channel protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001171752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Both variants 2, 3, and 5 all encode the same isoform (2).
      Source sequence(s)
      AL392111, BC000165, BE545584, BU171142
      Consensus CDS
      CCDS7348.1
      UniProtKB/Swiss-Prot
      P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
      UniProtKB/TrEMBL
      A0A024QZT0, A0A0A0MR02
      Related
      ENSP00000443092.1, ENST00000543351.5
      Conserved Domains (1) summary
      cd07306
      Location:15293
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    3. NM_001324087.2NP_001311016.1  voltage-dependent anion-selective channel protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 6 and 7, encodes isoform 3.
      Source sequence(s)
      AL390034, AL392111
      UniProtKB/TrEMBL
      A0A0A0MR02, B4DKM5
      Conserved Domains (1) summary
      cd07306
      Location:12254
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    4. NM_001324088.2NP_001311017.1  voltage-dependent anion-selective channel protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 2 and 3, encodes isoform 2.
      Source sequence(s)
      AL390034, AL392111
      Consensus CDS
      CCDS7348.1
      UniProtKB/Swiss-Prot
      P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
      UniProtKB/TrEMBL
      A0A024QZT0, A0A0A0MR02
      Conserved Domains (1) summary
      cd07306
      Location:15293
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    5. NM_001324089.2NP_001311018.1  voltage-dependent anion-selective channel protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 7, encodes isoform 3.
      Source sequence(s)
      AL390034, AL392111
      UniProtKB/TrEMBL
      A0A0A0MR02, B4DKM5
      Conserved Domains (1) summary
      cd07306
      Location:12254
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    6. NM_001324090.2NP_001311019.1  voltage-dependent anion-selective channel protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 4 and 6, encodes isoform 3.
      Source sequence(s)
      AL390034, AL392111
      UniProtKB/TrEMBL
      A0A0A0MR02, B4DKM5
      Conserved Domains (1) summary
      cd07306
      Location:12254
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    7. NM_001391963.1NP_001378892.1  voltage-dependent anion-selective channel protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL390034, AL392111
      Consensus CDS
      CCDS7348.1
      UniProtKB/Swiss-Prot
      P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
      UniProtKB/TrEMBL
      A0A024QZT0, A0A0A0MR02
      Related
      ENSP00000361686.3, ENST00000332211.11
      Conserved Domains (1) summary
      cd07306
      Location:15293
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    8. NM_003375.5NP_003366.2  voltage-dependent anion-selective channel protein 2 isoform 2

      See identical proteins and their annotated locations for NP_003366.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2, 3, and 5 all encode the same isoform (2).
      Source sequence(s)
      AL390034, AL392111
      Consensus CDS
      CCDS7348.1
      UniProtKB/Swiss-Prot
      P45880, Q5VWK1, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
      UniProtKB/TrEMBL
      A0A024QZT0, A0A0A0MR02
      Conserved Domains (1) summary
      cd07306
      Location:15293
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      75210170..75231448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      76083655..76104942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)