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    Josd1 Josephin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 74158, updated on 26-Sep-2022

    Summary

    Official Symbol
    Josd1provided by MGI
    Official Full Name
    Josephin domain containing 1provided by MGI
    Primary source
    MGI:MGI:1921408
    See related
    Ensembl:ENSMUSG00000022426 AllianceGenome:MGI:1921408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0063; 1300006C06Rik
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human JOSD1 (Josephin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.3), adrenal adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Josd1 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79558451..79572073, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79674250..79687872, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene chibby family member 1, beta catenin antagonist Neighboring gene predicted gene, 30877 Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene GTP binding protein 1 Neighboring gene Sad1 and UNC84 domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6306, MGC101975

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    josephin-1
    Names
    josephin domain-containing protein 1
    NP_083068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028792.3NP_083068.1  josephin-1

      See identical proteins and their annotated locations for NP_083068.1

      Status: VALIDATED

      Source sequence(s)
      AC118227
      Consensus CDS
      CCDS27647.1
      UniProtKB/Swiss-Prot
      Q3U3E9, Q9DBJ6
      UniProtKB/TrEMBL
      A0A8C6GA21
      Related
      ENSMUSP00000023061.6, ENSMUST00000023061.7
      Conserved Domains (1) summary
      pfam02099
      Location:31173
      Josephin; Josephin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79558451..79572073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)