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    Errfi1 ERBB receptor feedback inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74155, updated on 23-Jun-2021

    Summary

    Official Symbol
    Errfi1provided by MGI
    Official Full Name
    ERBB receptor feedback inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1921405
    See related
    Ensembl:ENSMUSG00000028967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R; Mig-; Mig6; RALT; Mig-6; AI788755; 1300002F13Rik
    Expression
    Broad expression in liver adult (RPKM 96.9), kidney adult (RPKM 81.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Errfi1 in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150938253..150953346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150853796..150868889)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (150229200..150242989)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42356 Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ribosomal protein S15A, pseudogene 3 Neighboring gene Parkinson disease (autosomal recessive, early onset) 7 Neighboring gene tumor necrosis factor receptor superfamily, member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ERBB receptor feedback inhibitor 1
    Names
    mitogen-inducible gene 6 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356323.1NP_001343252.1  ERBB receptor feedback inhibitor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK166791, AL607084, BP754554
      Consensus CDS
      CCDS18974.1
      Related
      ENSMUSP00000073285.3, ENSMUST00000073600.9
      Conserved Domains (2) summary
      pfam09027
      Location:448
      GTPase_binding; GTPase binding
      pfam11555
      Location:314366
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    2. NM_133753.2NP_598514.1  ERBB receptor feedback inhibitor 1

      See identical proteins and their annotated locations for NP_598514.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK166791, BB870611, BP754554
      Consensus CDS
      CCDS18974.1
      UniProtKB/Swiss-Prot
      Q99JZ7
      UniProtKB/TrEMBL
      Q3TK48
      Related
      ENSMUSP00000030811.2, ENSMUST00000030811.2
      Conserved Domains (2) summary
      pfam09027
      Location:448
      GTPase_binding; GTPase binding
      pfam11555
      Location:314366
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150938253..150953346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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