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    Errfi1 ERBB receptor feedback inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74155, updated on 14-Oct-2018

    Summary

    Official Symbol
    Errfi1provided by MGI
    Official Full Name
    ERBB receptor feedback inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1921405
    See related
    Ensembl:ENSMUSG00000028967 Vega:OTTMUSG00000010157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mig6; RALT; Mig-6; AI788755; 1300002F13Rik
    Expression
    Broad expression in liver adult (RPKM 96.9), kidney adult (RPKM 81.7) and 23 other tissues See more
    Orthologs

    Genomic context

    See Errfi1 in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (150853801..150868889)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (150229200..150242989)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36806 Neighboring gene predicted gene, 42356 Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene 40S ribosomal protein S15a-like Neighboring gene Parkinson disease (autosomal recessive, early onset) 7 Neighboring gene tumor necrosis factor receptor superfamily, member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epidermal growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    skin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ERBB receptor feedback inhibitor 1
    Names
    mitogen-inducible gene 6 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356323.1NP_001343252.1  ERBB receptor feedback inhibitor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK166791, AL607084, BP754554
      Conserved Domains (2) summary
      pfam09027
      Location:448
      GTPase_binding; GTPase binding
      pfam11555
      Location:314366
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    2. NM_133753.2NP_598514.1  ERBB receptor feedback inhibitor 1

      See identical proteins and their annotated locations for NP_598514.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK166791, BB870611, BP754554
      Consensus CDS
      CCDS18974.1
      UniProtKB/Swiss-Prot
      Q99JZ7
      UniProtKB/TrEMBL
      Q3TK48
      Related
      ENSMUSP00000030811.1, OTTMUSP00000010785, ENSMUST00000030811.1
      Conserved Domains (2) summary
      pfam09027
      Location:448
      GTPase_binding; GTPase binding
      pfam11555
      Location:314366
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      150853801..150868889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539210.1XP_006539273.1  ERBB receptor feedback inhibitor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q99JZ7
      UniProtKB/TrEMBL
      Q3TK48
      Related
      ENSMUSP00000073285.2, OTTMUSP00000010786, ENSMUST00000073600.8, OTTMUST00000023607
      Conserved Domains (2) summary
      pfam09027
      Location:448
      GTPase_binding; GTPase binding
      pfam11555
      Location:314366
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187025.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1160033..1173814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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