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    Errfi1 ERBB receptor feedback inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74155, updated on 18-Apr-2024

    Summary

    Official Symbol
    Errfi1provided by MGI
    Official Full Name
    ERBB receptor feedback inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1921405
    See related
    Ensembl:ENSMUSG00000028967 AllianceGenome:MGI:1921405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mig6; RALT; Mig-6; 1300002F13Rik
    Summary
    Predicted to enable SH3 domain binding activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including lung development; negative regulation of epidermal growth factor-activated receptor activity; and skin morphogenesis. Located in cytoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in alveolar system; lung; and lung epithelium. Used to study endometrial cancer and osteoarthritis. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 96.9), kidney adult (RPKM 81.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    4 E2; 4 81.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150938253..150953346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150853796..150868889)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42356 Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ribosomal protein S15A, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E10293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:150271076-150271277 Neighboring gene STARR-seq mESC enhancer starr_12178 Neighboring gene Parkinson disease (autosomal recessive, early onset) 7 Neighboring gene STARR-positive B cell enhancer ABC_E2733 Neighboring gene tumor necrosis factor receptor superfamily, member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bile acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fat pad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within limb joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within progesterone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to 1-oleoyl-sn-glycerol 3-phosphate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to estradiol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to progesterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to progesterone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to steroid hormone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within uterine epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ERBB receptor feedback inhibitor 1
    Names
    mitogen-inducible gene 6 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356323.1NP_001343252.1  ERBB receptor feedback inhibitor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK166791, AL607084, BP754554
      Consensus CDS
      CCDS18974.1
      UniProtKB/Swiss-Prot
      Q99JZ7
      UniProtKB/TrEMBL
      Q3TJN8, Q3TK48
      Related
      ENSMUSP00000073285.3, ENSMUST00000073600.9
      Conserved Domains (2) summary
      pfam09027
      Location:448
      GTPase_binding; GTPase binding
      pfam11555
      Location:314366
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    2. NM_133753.2NP_598514.1  ERBB receptor feedback inhibitor 1

      See identical proteins and their annotated locations for NP_598514.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK166791, BB870611, BP754554
      Consensus CDS
      CCDS18974.1
      UniProtKB/Swiss-Prot
      Q99JZ7
      UniProtKB/TrEMBL
      Q3TJN8, Q3TK48
      Related
      ENSMUSP00000030811.2, ENSMUST00000030811.2
      Conserved Domains (2) summary
      pfam09027
      Location:448
      GTPase_binding; GTPase binding
      pfam11555
      Location:314366
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150938253..150953346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)