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    Opa1 OPA1, mitochondrial dynamin like GTPase [ Mus musculus (house mouse) ]

    Gene ID: 74143, updated on 14-Sep-2021

    Summary

    Official Symbol
    Opa1provided by MGI
    Official Full Name
    OPA1, mitochondrial dynamin like GTPaseprovided by MGI
    Primary source
    MGI:MGI:1921393
    See related
    Ensembl:ENSMUSG00000038084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    l; lilr3; AI225888; AI847218; mKIAA0567; 1200011N24Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 11.0), CNS E18 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Opa1 in Genome Data Viewer
    Location:
    16 B2; 16 20.65 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (29398099..29481924)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (29579281..29663127)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (29579428..29652576)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene phospholipase A and acyltransferase 1 Neighboring gene ATPase type 13A5 Neighboring gene ATPase type 13A4 Neighboring gene zinc finger protein 788 pseudogene Neighboring gene predicted gene, 32740 Neighboring gene predicted gene, 46567 Neighboring gene predicted gene, 32679

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cardiolipin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner mitochondrial membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extrinsic component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynamin-like 120 kDa protein, mitochondrial
    Names
    large GTP-binding protein
    largeG
    optic atrophy 1 homolog
    optic atrophy protein 1 homolog
    NP_001186106.1
    NP_598513.1
    XP_006522717.2
    XP_006522718.2
    XP_006522719.2
    XP_006522720.2
    XP_030105167.1
    XP_036016055.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199177.1NP_001186106.1  dynamin-like 120 kDa protein, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154438, AK004715, CB249413
      Consensus CDS
      CCDS57024.1
      UniProtKB/TrEMBL
      H7BX01
      Related
      ENSMUSP00000036993.7, ENSMUST00000038867.13
      Conserved Domains (1) summary
      cd08771
      Location:305579
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    2. NM_133752.3NP_598513.1  dynamin-like 120 kDa protein, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_598513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC154438, AK029157, CB249413
      Consensus CDS
      CCDS28096.1
      UniProtKB/Swiss-Prot
      P58281
      Related
      ENSMUSP00000124223.2, ENSMUST00000160597.8
      Conserved Domains (1) summary
      cd08771
      Location:287561
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      29398099..29481924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522656.5XP_006522719.2  dynamin-like 120 kDa protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd08771
      Location:427701
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    2. XM_006522655.3XP_006522718.2  dynamin-like 120 kDa protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd08771
      Location:427701
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    3. XM_006522654.4XP_006522717.2  dynamin-like 120 kDa protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd08771
      Location:427701
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    4. XM_030249307.1XP_030105167.1  dynamin-like 120 kDa protein, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd08771
      Location:409683
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    5. XM_036160162.1XP_036016055.1  dynamin-like 120 kDa protein, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd08771
      Location:372646
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    6. XM_006522657.4XP_006522720.2  dynamin-like 120 kDa protein, mitochondrial isoform X2

      Related
      ENSMUSP00000123880.2, ENSMUST00000161186.8
      Conserved Domains (1) summary
      cd08771
      Location:409683
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
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