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    Armc8 armadillo repeat containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 74125, updated on 31-Jan-2019

    Summary

    Official Symbol
    Armc8provided by MGI
    Official Full Name
    armadillo repeat containing 8provided by MGI
    Primary source
    MGI:MGI:1921375
    See related
    Ensembl:ENSMUSG00000032468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid5; HSPC056; 1200015K23Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.3), whole brain E14.5 (RPKM 9.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Armc8 in Genome Data Viewer
    Location:
    9; 9 E3.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (99478385..99568944, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (99378810..99469318, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39412 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene NME/NM23 family member 9 Neighboring gene debranching RNA lariats 1 Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    armadillo repeat-containing protein 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166138.1NP_001159610.1  armadillo repeat-containing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001159610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK004793, AK078280, AK083094, BC038866
      Consensus CDS
      CCDS81059.1
      UniProtKB/Swiss-Prot
      Q9DBR3
      Related
      ENSMUSP00000139973.1, ENSMUST00000185524.6
      Conserved Domains (2) summary
      cd00020
      Location:57172
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:5790
      ARM; armadillo repeat [structural motif]
    2. NM_028768.3NP_083044.2  armadillo repeat-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_083044.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC156497, AK004793
      Consensus CDS
      CCDS23434.1
      UniProtKB/Swiss-Prot
      Q9DBR3
      UniProtKB/TrEMBL
      G3X920
      Related
      ENSMUSP00000035043.5, ENSMUST00000035043.11
      Conserved Domains (3) summary
      cd00020
      Location:57172
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00044
      Location:553583
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:5790
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      99478385..99568944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511511.3XP_006511574.1  armadillo repeat-containing protein 8 isoform X1

      Conserved Domains (2) summary
      cd00020
      Location:57172
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:5790
      ARM; armadillo repeat [structural motif]
    2. XM_006511512.3XP_006511575.1  armadillo repeat-containing protein 8 isoform X2

      Conserved Domains (3) summary
      cd00020
      Location:15130
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00044
      Location:511541
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:1548
      ARM; armadillo repeat [structural motif]
    3. XM_006511513.3XP_006511576.1  armadillo repeat-containing protein 8 isoform X3

      Conserved Domains (3) summary
      COG5369
      Location:378613
      COG5369; Uncharacterized conserved protein [Function unknown]
      sd00043
      Location:5790
      ARM; armadillo repeat [structural motif]
      cl25709
      Location:49212
      Arm_3; Atypical Arm repeat
    4. XM_006511515.3XP_006511578.1  armadillo repeat-containing protein 8 isoform X4

      Conserved Domains (3) summary
      cd00020
      Location:57172
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:5790
      ARM; armadillo repeat [structural motif]
      cl22454
      Location:482584
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
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