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    Actr3 ARP3 actin-related protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 74117, updated on 31-Jan-2019

    Summary

    Official Symbol
    Actr3provided by MGI
    Official Full Name
    ARP3 actin-related protein 3provided by MGI
    Primary source
    MGI:MGI:1921367
    See related
    Ensembl:ENSMUSG00000026341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp3; 1200003A09Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 60.4), CNS E14 (RPKM 36.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Actr3 in Genome Data Viewer
    Location:
    1; 1 E2.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (125392905..125435727, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (127289483..127332067, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene dipeptidylpeptidase 10 Neighboring gene predicted gene, 41941 Neighboring gene predicted gene, 35355 Neighboring gene solute carrier family 35, member F5 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC118188

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-gamma IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic chromosome movement towards spindle pole IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bleb assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myosin II filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    spindle localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    apical ectoplasmic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    apical tubulobulbar complex ISO
    Inferred from Sequence Orthology
    more info
     
    basal ectoplasmic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    concave side of sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    hemidesmosome ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    leading edge of lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    podosome ISO
    Inferred from Sequence Orthology
    more info
     
    podosome core ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-related protein 3
    Names
    ARP3 actin-related protein 3 homolog
    actin-like protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205385.1NP_001192314.1  actin-related protein 3

      See identical proteins and their annotated locations for NP_001192314.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124528, AC166158
      Consensus CDS
      CCDS15242.1
      UniProtKB/Swiss-Prot
      Q99JY9
      UniProtKB/TrEMBL
      Q3ULF7
      Related
      ENSMUSP00000027579.10, ENSMUST00000027579.16
      Conserved Domains (1) summary
      cl25542
      Location:2417
      Actin; Actin
    2. NM_001205386.1NP_001192315.1  actin-related protein 3

      See identical proteins and their annotated locations for NP_001192315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124528, AK166529, AV137086
      Consensus CDS
      CCDS15242.1
      UniProtKB/Swiss-Prot
      Q99JY9
      UniProtKB/TrEMBL
      Q3ULF7
      Conserved Domains (1) summary
      cl25542
      Location:2417
      Actin; Actin
    3. NM_023735.2NP_076224.1  actin-related protein 3

      See identical proteins and their annotated locations for NP_076224.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124528, AK145536, AV137086
      Consensus CDS
      CCDS15242.1
      UniProtKB/Swiss-Prot
      Q99JY9
      UniProtKB/TrEMBL
      Q3ULF7
      Related
      ENSMUSP00000137503.1, ENSMUST00000178474.7
      Conserved Domains (1) summary
      cl25542
      Location:2417
      Actin; Actin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      125392905..125435727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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