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    Actr3 ARP3 actin-related protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 74117, updated on 5-Sep-2021

    Summary

    Official Symbol
    Actr3provided by MGI
    Official Full Name
    ARP3 actin-related protein 3provided by MGI
    Primary source
    MGI:MGI:1921367
    See related
    Ensembl:ENSMUSG00000026341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Arp3; 1200003A09Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 60.4), CNS E14 (RPKM 36.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Actr3 in Genome Data Viewer
    Location:
    1; 1 E2.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (125320642..125363464, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (125392905..125435727, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (127289483..127332067, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dipeptidylpeptidase 10 Neighboring gene predicted gene, 53534 Neighboring gene predicted gene, 35355 Neighboring gene solute carrier family 35, member F5 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC118188

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to interferon-gamma IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within meiotic chromosome movement towards spindle pole IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within meiotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bleb assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of myosin II filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spindle localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical ectoplasmic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    part_of apical tubulobulbar complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal ectoplasmic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in concave side of sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in hemidesmosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in leading edge of lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome core ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-related protein 3
    Names
    ARP3 actin-related protein 3 homolog
    actin-like protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205385.1NP_001192314.1  actin-related protein 3

      See identical proteins and their annotated locations for NP_001192314.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124528, AC166158
      Consensus CDS
      CCDS15242.1
      UniProtKB/Swiss-Prot
      Q99JY9
      UniProtKB/TrEMBL
      Q3ULF7
      Related
      ENSMUSP00000027579.11, ENSMUST00000027579.17
      Conserved Domains (1) summary
      PTZ00280
      Location:2417
      PTZ00280; Actin-related protein 3; Provisional
    2. NM_001205386.1NP_001192315.1  actin-related protein 3

      See identical proteins and their annotated locations for NP_001192315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124528, AK166529, AV137086
      Consensus CDS
      CCDS15242.1
      UniProtKB/Swiss-Prot
      Q99JY9
      UniProtKB/TrEMBL
      Q3ULF7
      Conserved Domains (1) summary
      PTZ00280
      Location:2417
      PTZ00280; Actin-related protein 3; Provisional
    3. NM_023735.2NP_076224.1  actin-related protein 3

      See identical proteins and their annotated locations for NP_076224.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124528, AK145536, AV137086
      Consensus CDS
      CCDS15242.1
      UniProtKB/Swiss-Prot
      Q99JY9
      UniProtKB/TrEMBL
      Q3ULF7
      Related
      ENSMUSP00000137503.2, ENSMUST00000178474.8
      Conserved Domains (1) summary
      PTZ00280
      Location:2417
      PTZ00280; Actin-related protein 3; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      125320642..125363464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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