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    Crot carnitine O-octanoyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 74114, updated on 18-Sep-2024

    Summary

    Official Symbol
    Crotprovided by MGI
    Official Full Name
    carnitine O-octanoyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1921364
    See related
    Ensembl:ENSMUSG00000003623 AllianceGenome:MGI:1921364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200003H03Rik
    Summary
    Enables carnitine O-octanoyltransferase activity. Involved in carnitine metabolic process; coenzyme A metabolic process; and fatty acid metabolic process. Acts upstream of or within fatty acid transport. Located in peroxisome. Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 39.3), liver E18 (RPKM 15.1) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crot in Genome Data Viewer
    Location:
    5 A1; 5 3.5 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9016033..9047926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8966033..8997146, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 4 Neighboring gene STARR-seq mESC enhancer starr_12399 Neighboring gene calponin 3, acidic pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6299 Neighboring gene predicted gene, 31388 Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene STARR-seq mESC enhancer starr_12403 Neighboring gene predicted gene, 40264 Neighboring gene STARR-seq mESC enhancer starr_12404 Neighboring gene STARR-seq mESC enhancer starr_12405 Neighboring gene STARR-seq mESC enhancer starr_12406 Neighboring gene transmembrane protein 243, mitochondrial Neighboring gene cyclin D binding myb like transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carnitine O-octanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carnitine O-octanoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carnitine O-octanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisomal carnitine O-octanoyltransferase
    Names
    COT
    NP_001404759.1
    NP_001404760.1
    NP_001404761.1
    NP_001404762.1
    NP_076222.1
    XP_006503673.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417830.1NP_001404759.1  peroxisomal carnitine O-octanoyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC107763
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50
    2. NM_001417831.1NP_001404760.1  peroxisomal carnitine O-octanoyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC107763
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50
    3. NM_001417832.1NP_001404761.1  peroxisomal carnitine O-octanoyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC107763
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50
    4. NM_001417833.1NP_001404762.1  peroxisomal carnitine O-octanoyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC107763
      UniProtKB/TrEMBL
      Q3V3N1
    5. NM_023733.3NP_076222.1  peroxisomal carnitine O-octanoyltransferase isoform a

      See identical proteins and their annotated locations for NP_076222.1

      Status: VALIDATED

      Source sequence(s)
      AK004567
      Consensus CDS
      CCDS19087.1
      UniProtKB/Swiss-Prot
      Q921I4, Q9DC50
      Related
      ENSMUSP00000003720.5, ENSMUST00000003720.5
      Conserved Domains (1) summary
      pfam00755
      Location:20603
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    RNA

    1. NR_184637.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      9016033..9047926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503610.4XP_006503673.1  peroxisomal carnitine O-octanoyltransferase isoform X2

      Conserved Domains (1) summary
      pfam00755
      Location:152531
      Carn_acyltransf; Choline/Carnitine o-acyltransferase