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    Usp16 ubiquitin specific peptidase 16 [ Mus musculus (house mouse) ]

    Gene ID: 74112, updated on 2-Oct-2018

    Summary

    Official Symbol
    Usp16provided by MGI
    Official Full Name
    ubiquitin specific peptidase 16provided by MGI
    Primary source
    MGI:MGI:1921362
    See related
    Ensembl:ENSMUSG00000025616 Vega:OTTMUSG00000026485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBPM; 1200004E02Rik; 2810483I07Rik; 6330514E22Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 10.7), CNS E11.5 (RPKM 8.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Usp16 in Genome Data Viewer
    Location:
    16; 16 C3.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (87454708..87483515)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (87455230..87483760)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene RWD domain containing 2B Neighboring gene RIKEN cDNA B130034C11 gene Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) Neighboring gene ribosomal protein L31, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2A K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    monoubiquitinated histone H2A deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translational elongation ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 16
    Names
    deubiquitinating enzyme 16
    ubiquitin specific protease 16
    ubiquitin thioesterase 16
    ubiquitin thiolesterase 16
    ubiquitin-specific-processing protease 16
    NP_077220.2
    XP_006523163.1
    XP_006523164.1
    XP_006523165.1
    XP_017172635.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024258.2NP_077220.2  ubiquitin carboxyl-terminal hydrolase 16

      See identical proteins and their annotated locations for NP_077220.2

      Status: VALIDATED

      Source sequence(s)
      AC154631, AK160038, BE853521
      Consensus CDS
      CCDS28291.1
      UniProtKB/Swiss-Prot
      Q99LG0
      Related
      ENSMUSP00000026710.5, OTTMUSP00000032641, ENSMUST00000026710.11, OTTMUST00000065480
      Conserved Domains (3) summary
      cd02667
      Location:624822
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:633821
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      87454708..87483515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523101.1XP_006523164.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X2

      Conserved Domains (3) summary
      cd02667
      Location:623821
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:632820
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. XM_017317146.1XP_017172635.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X4

      Conserved Domains (3) summary
      cd02667
      Location:258456
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:135
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:267455
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. XM_006523100.2XP_006523163.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X1

      See identical proteins and their annotated locations for XP_006523163.1

      UniProtKB/Swiss-Prot
      Q99LG0
      Conserved Domains (3) summary
      cd02667
      Location:624822
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:633821
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    4. XM_006523102.3XP_006523165.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

      Conserved Domains (3) summary
      cd02667
      Location:315513
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:4392
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:324512
      UCH; Ubiquitin carboxyl-terminal hydrolase
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