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    Usp16 ubiquitin specific peptidase 16 [ Mus musculus (house mouse) ]

    Gene ID: 74112, updated on 23-Jun-2021

    Summary

    Official Symbol
    Usp16provided by MGI
    Official Full Name
    ubiquitin specific peptidase 16provided by MGI
    Primary source
    MGI:MGI:1921362
    See related
    Ensembl:ENSMUSG00000025616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBP-; UBPM; 1200004E02Rik; 2810483I07Rik; 6330514E22Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 10.7), CNS E11.5 (RPKM 8.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Usp16 in Genome Data Viewer
    Location:
    16; 16 C3.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87251833..87280403)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87454985..87483515)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (87455230..87483760)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene predicted gene, 25896 Neighboring gene RWD domain containing 2B Neighboring gene RIKEN cDNA B130034C11 gene Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) Neighboring gene predicted gene, 24891

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H2A K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoubiquitinated histone H2A deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translational elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 16
    Names
    deubiquitinating enzyme 16
    ubiquitin specific protease 16
    ubiquitin thioesterase 16
    ubiquitin thiolesterase 16
    ubiquitin-specific-processing protease 16
    NP_077220.2
    XP_006523163.1
    XP_006523164.1
    XP_006523165.1
    XP_036016050.1
    XP_036016051.1
    XP_036016052.1
    XP_036016053.1
    XP_036016054.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024258.2NP_077220.2  ubiquitin carboxyl-terminal hydrolase 16

      See identical proteins and their annotated locations for NP_077220.2

      Status: VALIDATED

      Source sequence(s)
      AC154631, AK160038, BE853521
      Consensus CDS
      CCDS28291.1
      UniProtKB/Swiss-Prot
      Q99LG0
      Related
      ENSMUSP00000026710.6, ENSMUST00000026710.12
      Conserved Domains (3) summary
      COG5560
      Location:135823
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:624822
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      87251833..87280403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523101.3XP_006523164.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X2

      Related
      ENSMUSP00000114058.2, ENSMUST00000119504.8
      Conserved Domains (3) summary
      COG5207
      Location:3357
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02667
      Location:623821
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. XM_006523102.5XP_006523165.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

      Conserved Domains (2) summary
      COG5560
      Location:25514
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:315513
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    3. XM_036160159.1XP_036016052.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X4

      Conserved Domains (2) summary
      cd02667
      Location:258456
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:135
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    4. XM_036160158.1XP_036016051.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

      Conserved Domains (2) summary
      COG5560
      Location:25514
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:315513
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    5. XM_036160160.1XP_036016053.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X4

      Conserved Domains (2) summary
      cd02667
      Location:258456
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:135
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    6. XM_006523100.3XP_006523163.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X1

      See identical proteins and their annotated locations for XP_006523163.1

      UniProtKB/Swiss-Prot
      Q99LG0
      Conserved Domains (3) summary
      COG5560
      Location:135823
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:624822
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:48122
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    7. XM_036160161.1XP_036016054.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X4

      Conserved Domains (2) summary
      cd02667
      Location:258456
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:135
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    8. XM_036160157.1XP_036016050.1  ubiquitin carboxyl-terminal hydrolase 16 isoform X3

      Conserved Domains (2) summary
      COG5560
      Location:25514
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:315513
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    RNA

    1. XR_004939251.1 RNA Sequence

      Related
      ENSMUST00000144759.8
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