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    Abcb6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 74104, updated on 8-Jul-2021

    Summary

    Official Symbol
    Abcb6provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 6provided by MGI
    Primary source
    MGI:MGI:1921354
    See related
    Ensembl:ENSMUSG00000026198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200005B17Rik
    Expression
    Ubiquitous expression in liver adult (RPKM 38.1), colon adult (RPKM 25.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Abcb6 in Genome Data Viewer
    Location:
    1; 1 C4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75148284..75157066, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75171640..75180392, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (75168214..75176857, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene reticulophagy regulator family member 2 Neighboring gene zinc finger, AN1 type domain 2B Neighboring gene autophagy related 9A Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type heme transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ABC-type heme transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ABC-type transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ABC-type transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tetrapyrrole binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification of cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heme metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heme transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heme transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heme transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in melanosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in porphyrin-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in porphyrin-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in porphyrin-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skin development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tetrapyrrole metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endolysosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in melanosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family B member 6; ATP-binding cassette sub-family B member 6, mitochondrial
    Names
    ABC-type heme transporter ABCB6
    NP_076221.1
    XP_006496615.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023732.3NP_076221.1  ATP-binding cassette sub-family B member 6

      See identical proteins and their annotated locations for NP_076221.1

      Status: VALIDATED

      Source sequence(s)
      AC166150, AI843102, AK004605, AK151165
      Consensus CDS
      CCDS15065.1
      UniProtKB/Swiss-Prot
      Q9DC29
      Related
      ENSMUSP00000027396.9, ENSMUST00000027396.15
      Conserved Domains (4) summary
      cd03253
      Location:590825
      ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C
      COG5265
      Location:329823
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      pfam16185
      Location:6255
      MTABC_N; Mitochondrial ABC-transporter N-terminal five TM region
      cl00549
      Location:277544
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75148284..75157066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496552.4XP_006496615.1  ATP-binding cassette sub-family B member 6, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG5265
      Location:41535
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
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