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    Ddias DNA damage-induced apoptosis suppressor [ Mus musculus (house mouse) ]

    Gene ID: 74041, updated on 21-Feb-2019

    Summary

    Official Symbol
    Ddiasprovided by MGI
    Official Full Name
    DNA damage-induced apoptosis suppressorprovided by MGI
    Primary source
    MGI:MGI:1921291
    See related
    Ensembl:ENSMUSG00000030641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    noxin; 4632434I11Rik
    Expression
    Biased expression in testis adult (RPKM 4.8), liver E14 (RPKM 2.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ddias in Genome Data Viewer
    Location:
    7; 7 E1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (92857525..92874286, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (100006036..100022742, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4632427E13 gene Neighboring gene RAB30, member RAS oncogene family Neighboring gene predicted gene, 40448 Neighboring gene prolylcarboxypeptidase (angiotensinase C) Neighboring gene predicted gene, 31663

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cytokine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA damage-induced apoptosis suppressor protein
    Names
    nitric oxide-inducible gene protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080995.2NP_001074464.1  DNA damage-induced apoptosis suppressor protein

      See identical proteins and their annotated locations for NP_001074464.1

      Status: VALIDATED

      Source sequence(s)
      AC158138
      Consensus CDS
      CCDS40022.1
      UniProtKB/TrEMBL
      E9QLR9
      Conserved Domains (1) summary
      cl09930
      Location:8102
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    2. NM_001355126.1NP_001342055.1  DNA damage-induced apoptosis suppressor protein

      Status: VALIDATED

      Source sequence(s)
      AC158138
      Conserved Domains (1) summary
      cl09930
      Location:8102
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    3. NM_001368705.1NP_001355634.1  DNA damage-induced apoptosis suppressor protein

      Status: VALIDATED

      Source sequence(s)
      AC158138

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      92857525..92874286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508245.2XP_006508308.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/TrEMBL
      E9QLR9
      Related
      ENSMUSP00000032877.9, ENSMUST00000032877.10
      Conserved Domains (1) summary
      cl09930
      Location:8102
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    2. XM_006508246.2XP_006508309.1  DNA damage-induced apoptosis suppressor protein isoform X1

      UniProtKB/TrEMBL
      E9QLR9
      Conserved Domains (1) summary
      cl09930
      Location:8102
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028729.1: Suppressed sequence

      Description
      NM_028729.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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