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    Msl1 male specific lethal 1 [ Mus musculus (house mouse) ]

    Gene ID: 74026, updated on 9-Dec-2024

    Summary

    Official Symbol
    Msl1provided by MGI
    Official Full Name
    male specific lethal 1provided by MGI
    Primary source
    MGI:MGI:1921276
    See related
    Ensembl:ENSMUSG00000052915 AllianceGenome:MGI:1921276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msl-1; 2810017F12Rik; 4121402D02Rik; 4930463F05Rik
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Involved in chromatin remodeling and positive regulation of DNA-templated transcription. Located in nuclear speck. Part of MSL complex. Is expressed in embryo. Orthologous to human MSL1 (MSL complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.2), testis adult (RPKM 20.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Msl1 in Genome Data Viewer
    Location:
    11 D; 11 62.67 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98684214..98698685)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98793508..98807862)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor alpha Neighboring gene STARR-positive B cell enhancer ABC_E3018 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98636882-98637065 Neighboring gene nuclear receptor subfamily 1, group D, member 1 Neighboring gene predicted gene, 31862 Neighboring gene STARR-positive B cell enhancer ABC_E468 Neighboring gene predicted gene 12359 Neighboring gene STARR-positive B cell enhancer ABC_E5276 Neighboring gene exon junction complex subunit Neighboring gene Rap guanine nucleotide exchange factor (GEF)-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MSL complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MSL complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MSL complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    male-specific lethal 1 homolog
    Names
    MSL1-like 1
    hampin
    male-specific lethal 1-like 1
    male-specific lethal-1 homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361931.1NP_001348860.1  male-specific lethal 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL590963
      Consensus CDS
      CCDS88248.1
      Related
      ENSMUSP00000103111.4, ENSMUST00000107487.10
      Conserved Domains (1) summary
      pfam15275
      Location:461577
      PEHE; PEHE domain
    2. NM_001361932.1NP_001348861.1  male-specific lethal 1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK014463, AL590963, BC043039
      Consensus CDS
      CCDS88249.1
      Related
      ENSMUSP00000103109.2, ENSMUST00000107485.8
    3. NM_001361933.1NP_001348862.1  male-specific lethal 1 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK015496, AL590963
      Consensus CDS
      CCDS88250.1
      Related
      ENSMUSP00000043328.7, ENSMUST00000037930.13
      Conserved Domains (1) summary
      pfam15275
      Location:231347
      PEHE; PEHE domain
    4. NM_001361934.1NP_001348863.1  male-specific lethal 1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK161412, AL590963
    5. NM_028722.3NP_082998.2  male-specific lethal 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_082998.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK014463, AL590963, BC058629
      Consensus CDS
      CCDS25364.1
      UniProtKB/Swiss-Prot
      A3KFP2, A3KFP4, Q27QB3, Q3TTE5, Q6PDM1, Q80XS0, Q8BPN3, Q9CXF9, Q9D5C9
      Related
      ENSMUSP00000042792.3, ENSMUST00000037915.9
      Conserved Domains (1) summary
      pfam15275
      Location:477593
      PEHE; PEHE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98684214..98698685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_388540.5 RNA Sequence