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    Msl1 male specific lethal 1 [ Mus musculus (house mouse) ]

    Gene ID: 74026, updated on 5-Aug-2018

    Summary

    Official Symbol
    Msl1provided by MGI
    Official Full Name
    male specific lethal 1provided by MGI
    Primary source
    MGI:MGI:1921276
    See related
    Ensembl:ENSMUSG00000052915 Vega:OTTMUSG00000006405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msl-1; AA682082; 2810017F12Rik; 4121402D02Rik; 4930463F05Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.2), testis adult (RPKM 20.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Msl1 in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (98795468..98807862)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98657083..98669173)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor alpha Neighboring gene nuclear receptor subfamily 1, group D, member 1 Neighboring gene predicted gene, 31862 Neighboring gene predicted gene 12359 Neighboring gene cancer susceptibility candidate 3 Neighboring gene Rap guanine nucleotide exchange factor (GEF)-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4-K16 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    male-specific lethal 1 homolog
    Names
    MSL1-like 1
    hampin
    male-specific lethal 1-like 1
    male-specific lethal-1 homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361931.1NP_001348860.1  male-specific lethal 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL590963
      Conserved Domains (1) summary
      pfam15275
      Location:461577
      PEHE; PEHE domain
    2. NM_001361932.1NP_001348861.1  male-specific lethal 1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK014463, AL590963, BC043039
    3. NM_001361933.1NP_001348862.1  male-specific lethal 1 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK015496, AL590963
      Conserved Domains (1) summary
      pfam15275
      Location:231347
      PEHE; PEHE domain
    4. NM_001361934.1NP_001348863.1  male-specific lethal 1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK161412, AL590963
    5. NM_028722.3NP_082998.2  male-specific lethal 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_082998.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK014463, AL590963, BC058629
      Consensus CDS
      CCDS25364.1
      UniProtKB/Swiss-Prot
      Q6PDM1
      Related
      ENSMUSP00000042792.2, OTTMUSP00000006781, ENSMUST00000037915.8
      Conserved Domains (1) summary
      pfam15275
      Location:477593
      PEHE; PEHE domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      98795468..98807862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534351.2XP_006534414.1  male-specific lethal 1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q6PDM1
      Related
      ENSMUSP00000103111.3, OTTMUSP00000006782, ENSMUST00000107487.9, OTTMUST00000014590
      Conserved Domains (1) summary
      pfam15275
      Location:461577
      PEHE; PEHE domain
    2. XM_011249283.2XP_011247585.1  male-specific lethal 1 homolog isoform X2

      Conserved Domains (1) summary
      pfam15275
      Location:247363
      PEHE; PEHE domain
    3. XM_011249284.2XP_011247586.1  male-specific lethal 1 homolog isoform X3

      UniProtKB/Swiss-Prot
      Q6PDM1
      Related
      ENSMUSP00000043328.6, OTTMUSP00000006783, ENSMUST00000037930.12, OTTMUST00000014591
      Conserved Domains (1) summary
      pfam15275
      Location:231347
      PEHE; PEHE domain

    RNA

    1. XR_388540.3 RNA Sequence

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