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    Glyr1 glyoxylate reductase 1 homolog (Arabidopsis) [ Mus musculus (house mouse) ]

    Gene ID: 74022, updated on 23-Jun-2021

    Summary

    Official Symbol
    Glyr1provided by MGI
    Official Full Name
    glyoxylate reductase 1 homolog (Arabidopsis)provided by MGI
    Primary source
    MGI:MGI:1921272
    See related
    Ensembl:ENSMUSG00000022536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N; ND; NDF; Npac; AW545332; 2810419J22Rik; 3930401K13Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 46.0), whole brain E14.5 (RPKM 44.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Glyr1 in Genome Data Viewer
    Location:
    16 A1; 16 2.49 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4831766..4867780, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5013902..5049938, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (5013995..5050003, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 22 Neighboring gene rogdi homolog Neighboring gene ubinuclein 1 Neighboring gene predicted gene, 23483 Neighboring gene transmembrane protein 126A pseudogene Neighboring gene periplakin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative oxidoreductase GLYR1
    Names
    cytokine-like nuclear factor n-pac
    nuclear protein NP60

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079814.1NP_001073282.1  putative oxidoreductase GLYR1 isoform 1

      See identical proteins and their annotated locations for NP_001073282.1

      Status: VALIDATED

      Source sequence(s)
      AC163723, AI854082, AK151832, BY135011, CF174076
      Consensus CDS
      CCDS37244.1
      UniProtKB/TrEMBL
      D3YYT1
      Related
      ENSMUSP00000111510.2, ENSMUST00000115844.3
      Conserved Domains (3) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:267550
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      cl25423
      Location:209301
      NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins
    2. NM_001359747.1NP_001346676.1  putative oxidoreductase GLYR1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163723
      Conserved Domains (2) summary
      COG2084
      Location:198475
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      cl02554
      Location:121
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    3. NM_001359748.1NP_001346677.1  putative oxidoreductase GLYR1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163723
      Conserved Domains (3) summary
      COG2084
      Location:198481
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      cl02554
      Location:121
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
      cl25423
      Location:140232
      NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins
    4. NM_028720.2NP_082996.2  putative oxidoreductase GLYR1 isoform 2

      See identical proteins and their annotated locations for NP_082996.2

      Status: VALIDATED

      Source sequence(s)
      AI854082, AK152887, AK159476, BY135011
      Consensus CDS
      CCDS27930.1
      UniProtKB/Swiss-Prot
      Q922P9
      Related
      ENSMUSP00000023189.8, ENSMUST00000023189.15
      Conserved Domains (2) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:267544
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4831766..4867780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249304.2XP_030105164.1  putative oxidoreductase GLYR1 isoform X2

      Conserved Domains (2) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:187464
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    2. XM_030249303.2XP_030105163.1  putative oxidoreductase GLYR1 isoform X1

      Conserved Domains (3) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:187470
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      cl21454
      Location:129221
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_036160153.1XP_036016046.1  putative oxidoreductase GLYR1 isoform X3

      Conserved Domains (2) summary
      cd05836
      Location:690
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      cl21454
      Location:268349
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_003951842.2 RNA Sequence

    2. XR_004939249.1 RNA Sequence

    3. XR_004939250.1 RNA Sequence

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