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    Otud4 OTU domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 73945, updated on 5-Aug-2018

    Summary

    Official Symbol
    Otud4provided by MGI
    Official Full Name
    OTU domain containing 4provided by MGI
    Primary source
    MGI:MGI:1098801
    See related
    Ensembl:ENSMUSG00000036990 Vega:OTTMUSG00000037239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI449692; D8Ertd69e; mKIAA1046; 4930431L18Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 14.9), placenta adult (RPKM 12.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Otud4 in Genome Data Viewer
    Location:
    8 C1; 8 37.74 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (79639676..79677755)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (82163575..82201654)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic II pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene tumor protein D52, pseudogene Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Lys63-specific deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Lys63-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    OTU domain-containing protein 4
    NP_001074633.1
    NP_001242962.1
    XP_006531469.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081164.1NP_001074633.1  OTU domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001074633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC101687
      Consensus CDS
      CCDS57626.1
      UniProtKB/Swiss-Prot
      B2RRE7
      UniProtKB/TrEMBL
      A0A0R4J260
      Related
      ENSMUSP00000134097.1, OTTMUSP00000053620, ENSMUST00000173286.7, OTTMUST00000096037
      Conserved Domains (2) summary
      pfam12293
      Location:557643
      T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion
      cl19932
      Location:42121
      OTU; OTU-like cysteine protease
    2. NM_001256033.1NP_001242962.1  OTU domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001242962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC101687, AW494258, BC138373
      Consensus CDS
      CCDS57625.1
      UniProtKB/Swiss-Prot
      B2RRE7
      Related
      ENSMUSP00000133939.1, OTTMUSP00000053619, ENSMUST00000173078.7, OTTMUST00000096036
      Conserved Domains (2) summary
      pfam12293
      Location:558644
      T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion
      cl19932
      Location:42121
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      79639676..79677755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531406.3XP_006531469.1  OTU domain-containing protein 4 isoform X1

      Conserved Domains (2) summary
      pfam12293
      Location:493579
      T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion
      cl19932
      Location:356
      OTU; OTU-like cysteine protease
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