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    Dcaf4 DDB1 and CUL4 associated factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 73828, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dcaf4provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 4provided by MGI
    Primary source
    MGI:MGI:1921078
    See related
    Ensembl:ENSMUSG00000021222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr21; 1110018E21Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.8), CNS E18 (RPKM 8.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dcaf4 in Genome Data Viewer
    Location:
    12; 12 D1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (83520456..83541994)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (84861416..84882944)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 6 Neighboring gene RIKEN cDNA 1700030I03 gene Neighboring gene D4, zinc and double PHD fingers, family 3 Neighboring gene D4, zinc and double PHD fingers, family 3 pseudogene Neighboring gene zinc finger, FYVE domain containing 1 Neighboring gene H2A histone family, member Z pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 4
    Names
    WD repeat domain 21

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165256.1NP_001158728.1  DDB1- and CUL4-associated factor 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA763635, AC139382, BE988217, CK330131, CN722277, CX208460
      UniProtKB/TrEMBL
      A0A1Y7VNZ0
      Related
      ENSMUSP00000152717.1, ENSMUST00000223291.1
      Conserved Domains (3) summary
      COG2319
      Location:315484
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:299335
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:327484
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_030246.2NP_084522.1  DDB1- and CUL4-associated factor 4 isoform 2

      See identical proteins and their annotated locations for NP_084522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA763635, AC139382, BB852314, BE988217, CK330131, CN722277, CX208460
      Consensus CDS
      CCDS26027.1
      UniProtKB/TrEMBL
      Q99LF7
      Related
      ENSMUSP00000021645.7, ENSMUST00000021645.8
      Conserved Domains (3) summary
      COG2319
      Location:302471
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:286322
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:314471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      83520456..83541994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516284.2XP_006516347.1  DDB1- and CUL4-associated factor 4 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:72256
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:71107
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:99256
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006516282.1XP_006516345.1  DDB1- and CUL4-associated factor 4 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:314483
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:298334
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:326483
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006516283.2XP_006516346.1  DDB1- and CUL4-associated factor 4 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:149318
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:133169
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:161318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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