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    Thap1 THAP domain containing, apoptosis associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 73754, updated on 25-Jun-2018

    Summary

    Official Symbol
    Thap1provided by MGI
    Official Full Name
    THAP domain containing, apoptosis associated protein 1provided by MGI
    Primary source
    MGI:MGI:1921004
    See related
    Ensembl:ENSMUSG00000037214 Vega:OTTMUSG00000031061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW490810; 4833431A01Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 5.6), CNS E11.5 (RPKM 3.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Thap1 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (26158169..26164151)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (27268641..27274623)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene hook microtubule tethering protein 3 Neighboring gene calcium binding protein 39 pseudogene Neighboring gene ring finger protein 170 Neighboring gene predicted gene, 31727 Neighboring gene predicted gene, 31784

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Potential readthrough

    Included gene: Rnf170

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    THAP domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199042.2NP_950243.1  THAP domain-containing protein 1

      See identical proteins and their annotated locations for NP_950243.1

      Status: VALIDATED

      Source sequence(s)
      AC093366, AC154102
      Consensus CDS
      CCDS22208.1
      UniProtKB/Swiss-Prot
      Q8CHW1
      Related
      ENSMUSP00000042464.5, OTTMUSP00000040574, ENSMUST00000036807.12, OTTMUST00000076951
      Conserved Domains (1) summary
      smart00980
      Location:482
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      26158169..26164151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509202.3XP_006509265.1  THAP domain-containing protein 1 isoform X1

      Related
      ENSMUSP00000121153.1, OTTMUSP00000040575, ENSMUST00000130231.1, OTTMUST00000076952
      Conserved Domains (2) summary
      pfam05485
      Location:259
      THAP; THAP domain
      cl19756
      Location:117138
      I_LWEQ; I/LWEQ domain
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