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    Cby1 chibby family member 1, beta catenin antagonist [ Mus musculus (house mouse) ]

    Gene ID: 73739, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cby1provided by MGI
    Official Full Name
    chibby family member 1, beta catenin antagonistprovided by MGI
    Primary source
    MGI:MGI:1920989
    See related
    Ensembl:ENSMUSG00000022428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CBY; arb1; Pgea1; PGEA14; 1110014P06Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 22.6), CNS E14 (RPKM 12.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cby1 in Genome Data Viewer
    Location:
    15 E1; 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (79659156..79667662)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79489657..79498090)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A Neighboring gene predicted gene, 30877 Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary transition zone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centriole ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein chibby homolog 1
    Names
    PIGEA-14
    PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
    PKD2 interactor, golgi and endoplasmic reticulum associated 1
    chibby homolog 1
    cytosolic leucine-rich protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028634.3NP_082910.1  protein chibby homolog 1

      See identical proteins and their annotated locations for NP_082910.1

      Status: PROVISIONAL

      Source sequence(s)
      AC117806, AC118227
      Consensus CDS
      CCDS27645.1
      UniProtKB/Swiss-Prot
      Q9D1C2
      Related
      ENSMUSP00000023064.7, ENSMUST00000023064.8
      Conserved Domains (1) summary
      pfam14645
      Location:1114
      Chibby; Chibby family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      79659156..79667662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521484.3XP_006521547.1  protein chibby homolog 1 isoform X1

      Conserved Domains (1) summary
      pfam14645
      Location:23126
      Chibby; Chibby family
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